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Review
. 2021 May 14;26(10):2926.
doi: 10.3390/molecules26102926.

An Overview of the Chemical Characteristics, Bioactivity and Achievements Regarding the Therapeutic Usage of Acetogenins from Annona cherimola Mill

Alexandra G Durán  1 , M Teresa Gutiérrez  1 , Francisco J R Mejías  1 , José M G Molinillo  1 , Francisco A Macías  1
Affiliations
Review

An Overview of the Chemical Characteristics, Bioactivity and Achievements Regarding the Therapeutic Usage of Acetogenins from Annona cherimola Mill

Alexandra G Durán et al. Molecules. .

Abstract

Annona cherimola Mill., or the custard apple, is one of the species belonging to the Annonaceae family, is widely used in traditional medicine, and has been reported to be a valuable source of bioactive compounds. A unique class of secondary metabolites derived from this family are Annonaceous acetogenins, lipophilic polyketides considered to be amongst the most potent antitumor compounds. This review provides an overview of the chemical diversity, isolation procedures, bioactivity, modes of application and synthetic derivatives of acetogenins from A. cherimola Mill.

Keywords: Annona cherimola; acetogenin drug delivery; acetogenin encapsulation; acetogenin formulation; acetogenins; bioactivity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Overview of annonaceous ACG structure.
Figure 2
Figure 2
Most common structures of annonaceous acetogenins isolated from ACM.
Figure 3
Figure 3
Annonaceous acetogenins isolated from ACMs harvested at ‘Tropical Coast’.
Figure 4
Figure 4
Diagram of the SMPMs synthesis to encapsulate Annona cherimolia acetogenins. (Reproduced from 10.1016/j.colsurfb.2016.05.012 with permission from Elsevier B.V. under License Number: 5039230526812) [75].
Figure 5
Figure 5
Structures of bullatacin and AA005.
Figure 6
Figure 6
Carbohydrate precursors employed in the synthesis of Annona cherimola acetogenin mimics and mono-galactosylated squamocin.
See this image and copyright information in PMC

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