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Review
. 2021 May 14;10(10):2131.
doi: 10.3390/jcm10102131.

Limited Liver or Lung Colorectal Cancer Metastases. Systemic Treatment, Surgery, Ablation or SBRT

Meritxell Molla  1   2 , Julen Fernandez-Plana  3 , Santiago Albiol  4 , Constantino Fondevila  5 , Ivan Vollmer  6 , Carla Cases  1 , Angeles Garcia-Criado  6 , Jaume Capdevila  7 , Carles Conill  1 , Yliam Fundora  5 , Carlos Fernandez-Martos  8 , Estela Pineda  2   4
Affiliations
Review

Limited Liver or Lung Colorectal Cancer Metastases. Systemic Treatment, Surgery, Ablation or SBRT

Meritxell Molla et al. J Clin Med. .

Abstract

The prognosis for oligometastatic colorectal cancer has improved in recent years, mostly because of recent advances in new techniques and approaches to the treatment of oligometastases, including new surgical procedures, better systemic treatments, percutaneous ablation, and stereotactic body radiation therapy (SBRT). There are several factors to consider when deciding on the better approach for each patient: tumor factors (metachronous or synchronous metastases, RAS mutation, BRAF mutation, disease-free interval, size and number of metastases), patient factors (age, frailty, comorbidities, patient preferences), and physicians' factors (local expertise). These advances have presented major challenges and opportunities for oncologic multidisciplinary teams to treat patients with limited liver and lung metastases from colorectal cancer with a curative intention. In this review, we describe the different treatment options in patients with limited liver and lung metastases from colorectal cancer, and the possible combination of three approaches: systemic treatment, surgery, and local ablative treatments.

Keywords: ablation; colorectal cancer; liver metastases; lung metastases; oligometastasis; stereotactic body radiation therapy.

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Conflict of interest statement

The authors declare no conflict of interest

Figures

Figure 1
Figure 1
Lung metastases from CRC. Planning treatment: Dose: 60 Gy in 3 fractions. DBE: 150 Gy.
Figure 2
Figure 2
Liver metastases from CRC. Planning treatment. Dose: 55 Gy in 5 fractions. DBE: 116 Gy.
Figure 3
Figure 3
Treatment algorithm in limited liver and lung CRC metastases.
See this image and copyright information in PMC

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