Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May 14;14(10):2558.
doi: 10.3390/ma14102558.

Hard Dental Tissues Regeneration-Approaches and Challenges

Mihaela Olaru  1 , Liliana Sachelarie  2 , Gabriela Calin  2
Affiliations
Review

Hard Dental Tissues Regeneration-Approaches and Challenges

Mihaela Olaru et al. Materials (Basel). .

Abstract

With the development of the modern concept of tissue engineering approach and the discovery of the potential of stem cells in dentistry, the regeneration of hard dental tissues has become a reality and a priority of modern dentistry. The present review reports the recent advances on stem-cell based regeneration strategies for hard dental tissues and analyze the feasibility of stem cells and of growth factors in scaffolds-based or scaffold-free approaches in inducing the regeneration of either the whole tooth or only of its component structures.

Keywords: biomaterials; growth factors; hard dental tissues; scaffold-based and scaffold-free approach; stem cells; tooth regeneration.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the dental stem cells involved in tooth regeneration and the associated tissues from which these cells can be isolated.
Figure 2
Figure 2
Summary of stem cell therapy for inducing tooth regeneration (Adapted with permission from ref. [199]. Copyright 2018 Elsevier).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Beniash E., Stifler C.A., Sun C.-Y., Jung G.S., Qin Z., Buehler M.J., Pupa U.P., Gilbert A. The hidden structure of human enamel. Nat. Commun. 2019;10:4383. doi: 10.1038/s41467-019-12185-7. - DOI - PMC - PubMed
    1. Murata M., Akazawa T., Mitsugi M., Arafat M., Um I.W., Minamida Y., Kim K.W., Kim Y.K., Sun Y., Qin C. Autograft of dentin materials for bone regeneration. Adv. Biomater. Sci. Biomed. Appl. 2013;15:391–403.
    1. Yamamoto T., Hasegawa T., Yamamoto T., Hongo H., Amizuka N. Histology of human cementum: Its structure, function, and development. Jpn. Dent. Sci. Rev. 2016;52:63–74. doi: 10.1016/j.jdsr.2016.04.002. - DOI - PMC - PubMed
    1. Nazir M.A. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int. J. Health Sci. 2017;11:72–80. - PMC - PubMed
    1. Lacruz R.S., Habelitz S., Wright J.T., Paine M.L. Dental enamel formation and implications for oral health and disease. Physiol. Rev. 2017;97:939–993. doi: 10.1152/physrev.00030.2016. - DOI - PMC - PubMed

LinkOut - more resources