Hard Dental Tissues Regeneration-Approaches and Challenges

Abstract

With the development of the modern concept of tissue engineering approach and the discovery of the potential of stem cells in dentistry, the regeneration of hard dental tissues has become a reality and a priority of modern dentistry. The present review reports the recent advances on stem-cell based regeneration strategies for hard dental tissues and analyze the feasibility of stem cells and of growth factors in scaffolds-based or scaffold-free approaches in inducing the regeneration of either the whole tooth or only of its component structures.

Keywords: biomaterials; growth factors; hard dental tissues; scaffold-based and scaffold-free approach; stem cells; tooth regeneration.

Figure 1

Schematic representation of the dental stem cells involved in tooth regeneration and the associated tissues from which these cells can be isolated.

Figure 2

Summary of stem cell therapy for inducing tooth regeneration (Adapted with permission from ref. [199]. Copyright 2018 Elsevier).