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. 2021 May 19;13(10):2470.
doi: 10.3390/cancers13102470.

Clinical, Histological, and Molecular Features of Solitary Fibrous Tumor of Bone: A Single Institution Retrospective Review

Giuseppe Bianchi  1 , Debora Lana  1 , Marco Gambarotti  2 , Cristina Ferrari  3 , Marta Sbaraglia  4 , Elena Pedrini  5 , Laura Pazzaglia  3 , Luca Sangiorgi  5 , Isabella Bartolotti  5 , Angelo Paolo Dei Tos  6 , Katia Scotlandi  3 , Alberto Righi  2
Affiliations

Clinical, Histological, and Molecular Features of Solitary Fibrous Tumor of Bone: A Single Institution Retrospective Review

Giuseppe Bianchi et al. Cancers (Basel). .

Abstract

Primary solitary fibrous tumor (SFT) of the bone is extremely rare, with only few cases reported in the literature. We retrieved all cases of primary SFT of the bone treated at our institution and we assessed the morphology and the immunohistochemical and molecular features to investigate the clinical outcome of primary SFT of the bone and any clinical relevance of clinical and histological criteria of aggressiveness currently adopted for the soft tissues counterpart. Morphologically, 15 cases evidenced high cellularity, cytologic atypia, and foci of necrosis and were associated with more than 4 mitotic figures/10 HPF. Immunohistochemical analysis showed an expression of CD34 and of STAT6 immunopositivity in 95% and in 100% of cases, respectively. The presence of NAB2-STAT6 chimeric transcripts was found in 10 out of 12 cases in which RT-PCR analysis was feasible, whereas TERT promoter mutations analysis was feasible in 16 cases and only a C-to-T substitution in a heterozygous state was found in one DNA sample for the C228T genetic variant. P53 variants were assessed in 12 cases: 11 (91.6%) cases showed a variation, while in one case, no alteration was found. Disease-specific survival was 64% at 5 years and 49% at 10 years. Statistical analysis showed no correlation between survival and all the clinicopathological and molecular parameters evaluated. In conclusion, at difference to SFT of soft tissues, aggressive behavior of primary SFT of the bone seems to be independent from mitotic count or any other clinicopathological and molecular features.

Keywords: NAB2-STAT6 fusion transcripts; primary bone tumor; prognosis; risk stratification; solitary fibrous tumor.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Solitary fibrous tumor: A spindle cell proliferation showing hemangiopericytoma-like blood vessels is seen (Hematoxylin &Eosin, original magnification, ×100).
Figure 2
Figure 2
The nuclei of neoplastic cells express STAT6 (original magnification, ×200).
Figure 3
Figure 3
Cumulative survival of 24 patients affected by primary bone solitary fibrous tumor; stratification by metastases at presentation.
See this image and copyright information in PMC

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