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. 2021 May 19;9(5):612.
doi: 10.3390/healthcare9050612.

Burden of Treatment among Elderly Patients with Cancer: A Scoping Review

Adem Sav  1 , Sara S McMillan  2 , Adeola Akosile  1
Affiliations

Burden of Treatment among Elderly Patients with Cancer: A Scoping Review

Adem Sav et al. Healthcare (Basel). .

Abstract

Background: The objective of this scoping review is to understand how treatment burden is experienced in elderly patients with cancer and what the most prevalent dimensions of treatment burden are among this population. According to one conceptual model, there are six dimensions of treatment burden, including financial, medication, administrative, time/travel, lifestyle, and healthcare.

Methods: A scoping review methodology framework was used to collected data from EMBASE CINAHL (Cumulative Index to Nursing and Allied Health Literature), Medline/PubMed, Scopus, Web of Science, Embase, and Cochrane from 2000 to March 2020. Studies which focused on treatment burden among elderly patients with cancer (+65 years) were selected. Data were extracted using a standardized proforma.

Results: The results identified 3319 total papers. Of these, 24 met the inclusion criteria and were included in the scoping review. A significant proportion of these studies was conducted in the United States (n = 10) using self-reported, cross-sectional data. Financial burden was the most prevalent dimension of treatment burden, with 11 studies focusing on the direct and indirect costs associated with cancer treatment. Other but less obvious aspects of treatment burden elderly patients experienced included the length of time taken to access and administer treatment and medication-related burdens.

Conclusions: Emerging findings suggest that the financial aspects of cancer treatment are a significant burden for most elderly cancer patients. Personalized healthcare interventions targeting ways to reduce and screen for treatment burden, particularly those related to cost, are urgently needed.

Keywords: elderly cancer patients; financial burden; scoping review; treatment burden.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Conceptual framework of treatment burden (based on Sav et al., 2017).
Figure 2
Figure 2
Inclusion flowchart.
See this image and copyright information in PMC

References

    1. Arenas M., Nguyen N., Franco P., Selek U., Rovirosa A., Sabater S. Oncology: Management of elderly cancer patients. BioMed Res. Int. 2018;2018:1–2. doi: 10.1155/2018/7362585. - DOI - PMC - PubMed
    1. Henry D.H., Viswanathan H.N., Elkin E.P., Traina S., Wade S., Cella D. Symptoms and treatment burden associated with cancer treatment: Results from a cross-sectional national survey in the U.S. Support. Care Cancer. 2008;16:791–801. doi: 10.1007/s00520-007-0380-2. - DOI - PubMed
    1. Given B., Given C.W. Older adults and cancer treatment. Cancer. 2008;113:3505–3511. doi: 10.1002/cncr.23939. - DOI - PMC - PubMed
    1. Given B.A., Given C.W., Vachon E., Hershey D. Do we have a clue. Cancer Nurs. 2016;39:423–424. doi: 10.1097/NCC.0000000000000408. - DOI - PMC - PubMed
    1. Given B.A., Given C.W., Sherwood P. The challenge of quality cancer care for family caregivers. Semin. Oncol. Nurs. 2012;28:205–212. doi: 10.1016/j.soncn.2012.09.002. - DOI - PubMed

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