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. 2021 May 18;12(5):766.
doi: 10.3390/genes12050766.

Impact of Snoring on Telomere Shortening in Adolescents with Atopic Diseases

Keith T S Tung  1 , Rosa S Wong  1 , Hing-Wai Tsang  1 , Gilbert T Chua  1 , Dicky Chan  1 , Kate C Chan  2 , Wilfred H S Wong  1 , Jason C Yam  3 , Marco Ho  1 , Clement C Tham  3 , Ian C K Wong  4   5 , Godfrey C F Chan  1 , Patrick Ip  1
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Impact of Snoring on Telomere Shortening in Adolescents with Atopic Diseases

Keith T S Tung et al. Genes (Basel). .

Abstract

Atopic diseases can impose a significant burden on children and adolescents. Telomere length is a cellular marker of aging reflecting the impact of cumulative stress exposure on individual health. Since elevated oxidative stress and inflammation burden induced by chronic atopy and snoring may impact telomere length, this study aimed to investigate whether snoring would moderate the relationship between atopic diseases and telomere length in early adolescence. We surveyed 354 adolescents and their parents. Parents reported the adolescents' history of atopic diseases, recent snoring history as well as other family sociodemographic characteristics. Buccal swab samples were also collected from the adolescents for telomere length determination. Independent and combined effects of atopic diseases and snoring on telomere length were examined. Among the surveyed adolescents, 174 were reported by parents to have atopic diseases (20 had asthma, 145 had allergic rhinitis, 53 had eczema, and 25 had food allergy). Shorter TL was found in participants with a history of snoring and atopic diseases (β = -0.34, p = 0.002) particularly for asthma (β = -0.21, p = 0.007) and allergic rhinitis (β = -0.22, p = 0.023). Our findings suggest that snoring in atopic patients has important implications for accelerated telomere shortening. Proper management of atopic symptoms at an early age is important for the alleviation of long-term health consequences at the cellular level.

Keywords: adolescence; asthma; rhinitis; snoring; telomere length.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Telomere length of adolescents with or without snoring by a parent-reported history of (A) asthma, (B) allergic rhinitis, (C) eczema, (D) food allergy, (E) any atopic diseases. Note: * p < 0.05.
Figure 1
Figure 1
Telomere length of adolescents with or without snoring by a parent-reported history of (A) asthma, (B) allergic rhinitis, (C) eczema, (D) food allergy, (E) any atopic diseases. Note: * p < 0.05.
Figure 1
Figure 1
Telomere length of adolescents with or without snoring by a parent-reported history of (A) asthma, (B) allergic rhinitis, (C) eczema, (D) food allergy, (E) any atopic diseases. Note: * p < 0.05.
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References

    1. Christiansen E.S., Kjaer H.F., Eller E., Bindslev-Jensen C., Høst A., Mortz C.G., Halken S. The prevalence of atopic diseases and the patterns of sensitization in adolescence. Pediatric Allergy Immunol. 2016;27:847–853. doi: 10.1111/pai.12650. - DOI - PubMed
    1. Wong G.W.K., Hui D.S.C., Chan H.H., Fok T.F., Leung R., Zhong N.S., Chen Y.Z., Lai C.K.W. Prevalence of respiratory and atopic disorders in Chinese schoolchildren. Clin. Exp. Allergy. 2001;31:1225–1231. doi: 10.1046/j.1365-2222.2001.01140.x. - DOI - PubMed
    1. Sterner T., Uldahl A., Svensson Å., Björk J., Svedman C., Nielsen C., Tunsäter A., Bruze M., Kiotseridis H. The Southern Sweden Adolescent Allergy-Cohort: Prevalence of allergic diseases and cross-sectional associations with individual and social factors. J. Asthma Off. J. Assoc. Care Asthma. 2019;56:227–235. doi: 10.1080/02770903.2018.1452033. - DOI - PubMed
    1. Asher M.I., Montefort S., Björkstén B., Lai C.K., Strachan D.P., Weiland S.K., Williams H. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006;368:733–743. doi: 10.1016/S0140-6736(06)69283-0. - DOI - PubMed
    1. Wong G.W., Leung T.F., Ko F.W. Changing prevalence of allergic diseases in the Asia-pacific region. Allergy Asthma Immunol. Res. 2013;5:251–257. doi: 10.4168/aair.2013.5.5.251. - DOI - PMC - PubMed

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