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Review
. 2021 May 25;10(6):845.
doi: 10.3390/antiox10060845.

Inflammation and Oxidative Damage in Ischaemic Renal Disease

Áine M de Bhailís  1 , Constantina Chrysochou  1 , Philip A Kalra  1
Affiliations
Review

Inflammation and Oxidative Damage in Ischaemic Renal Disease

Áine M de Bhailís et al. Antioxidants (Basel). .

Abstract

Ischaemic renal disease as result of atherosclerotic renovascular disease activates a complex biological response that ultimately leads to fibrosis and chronic kidney disease. Large randomised control trials have shown that renal revascularisation in patients with atherosclerotic renal artery disease does not confer any additional benefit to medical therapy alone. This is likely related to the activation of complex pathways of oxidative stress, inflammatory cytokines and fibrosis due to atherosclerotic disease and hypoxic injury due to reduced renal blood flow. New evidence from pre-clinical trials now indicates a role for specific targeted therapeutic interventions to counteract this complex pathogenesis. This evidence now suggests that the focus for those with atherosclerotic renovascular disease should be a combination of revascularisation and renoprotective therapies that target the renal tissue response to ischaemia, reduce the inflammatory infiltrate and prevent or reduce the fibrosis.

Keywords: atherosclerotic renovascular disease; ischaemic renal disease; oxidative stress; renal inflammation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Role of oxidative stress in the pathophysiology of ischaemic nephropathy.
See this image and copyright information in PMC

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