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. 2021 May 30;10(11):2431.
doi: 10.3390/jcm10112431.

Associations between High-Density Lipoprotein Functionality and Major Adverse Cardiovascular Events in Patients Who Have Undergone Coronary Computed Tomography Angiography

Hiroko Inoue  1 , Yuhei Shiga  2 , Kenji Norimatsu  1   2 , Kohei Tashiro  2 , Makito Futami  1   2 , Yasunori Suematsu  2 , Makoto Sugihara  2 , Hiroaki Nishikawa  1 , Yousuke Katsuda  1 , Shin-Ichiro Miura  1   2
Affiliations

Associations between High-Density Lipoprotein Functionality and Major Adverse Cardiovascular Events in Patients Who Have Undergone Coronary Computed Tomography Angiography

Hiroko Inoue et al. J Clin Med. .

Abstract

The present study aimed to investigate the associations between high-density lipoprotein (HDL) functionality and major adverse cardiovascular events (MACE) in patients who have undergone coronary computed tomography angiography (CCTA). We performed a prospective cohort study and enrolled 151 patients who underwent CCTA and had a follow-up of up to 5 years. We measured cholesterol efflux capacity (CEC), caspase-3/7 activity and monocyte chemoattractant protein-1 (MCP-1) secretion as bioassays of HDL functionality. The patients were divided into MACE(-) (n = 138) and MACE(+) (n = 13) groups. While there was no significant difference in %CEC, caspase-3/7 activity or MCP-1 secretion between the MACE(-) and MACE(+) groups, total CEC and HDL cholesterol (HDL-C) in the MACE(+) group were significantly lower than those in the MACE(-) group. Total CEC was correlated with HDL-C. A receiver-operating characteristic curve analysis showed that there was no significant difference between the areas under the curves for total CEC and HDL-C. In conclusion, total CEC in addition to HDL-C, but not %CEC, was associated with the presence of MACE. On the other hand, HDL functionality with regard to anti-inflammatory and anti-apoptosis effects was not associated with MACE.

Keywords: cholesterol efflux capacity; high-density lipoprotein; major adverse cardiovascular events.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
(A) %CEC, (B) total CEC and (C) HDL-C in the MACE(+) and MACE(−) groups. A.U: arbitrary unit.
Figure 2
Figure 2
(A) Relative caspase 3/7 activity, (B) relative total caspase 3/7 activity, (C) relative secretion of MCP-1 and (D) relative total secretion of MCP-1 in the MACE(+) and MACE(−) groups. A.U: arbitrary unit.
Figure 3
Figure 3
Correlations between (A) %CEC, (B) total CEC and HDL-C in all patients. A.U: arbitrary unit.
Figure 4
Figure 4
Cut-off values of (A) total CEC or (B) HDL-C levels for the diagnosis of MACE in all patients.
See this image and copyright information in PMC

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