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. 2021 May 23;10(11):2256.
doi: 10.3390/jcm10112256.

Evaluation of the Efficacy of Lacer HaliTM Treatment on the Management of Halitosis: A Randomized Double-Blind Clinical Trial

Laiqi Xiang  1   2 , Rosa Rojo  3 , Juan Carlos Prados-Frutos  4   5
Affiliations

Evaluation of the Efficacy of Lacer HaliTM Treatment on the Management of Halitosis: A Randomized Double-Blind Clinical Trial

Laiqi Xiang et al. J Clin Med. .

Abstract

Background: Halitosis of oral origin is very common in the general population. Due to their antimicrobial properties, chlorhexidine-based products are widely used in the management of this condition, but these are associated with reversible side effects. In this study we evaluated the efficacy of Lacer HaliTM mouthrinse and toothpaste in subjects with intraoral halitosis after several applications under normal conditions of use.

Methods: In this randomized clinical trial with mouth rinse and toothpaste, single-center, double-blinded, parallel participants were assigned to an experimental group (Lacer HaliTM,, n = 20), a positive control group (HalitaTM, n = 20), and a placebo group (n = 20). The active duration of the study was 18 days. The clinical follow-up evaluations were performed at five time points (T0, T1, T2, T3, and T4). The intensity of halitosis was evaluated by organoleptic measurement and the portable gas chromatograph OralChromaTM. The data were analyzed using generalized mixed linear models.

Results: Sixty patients completed the study. Lacer HaliTM, in comparison with HalitaTM, did not show statistically significant differences at any time during the study except for the levels of hydrogen sulfide and total volatile sulfur compounds at 15 days, where HalitaTM was better. Compared to the placebo treatment, Lacer HaliTM, was significantly more efficient, in terms of both the organoleptic evaluations at 8 days and the levels of hydrogen sulfide.

Conclusions: Lacer HaliTM is an alternative to chlorhexidine-based toothpaste and mouthwashes in the management of halitosis.

Keywords: Lacer HaliTM; OralChromaTM; halitosis; octenidine; oral malodor; organoleptic score.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
CONSORT flow chart of the study patients.
Figure 2
Figure 2
Mean perceived odor and standard deviation at different times for the organoleptic test. *: Statistically significant results (p < 0.05) between the placebo and Lacer HaliTM groups were found. No significant differences were found between the HalitaTM and Lacer HaliTM groups.
Figure 3
Figure 3
Mean average hydrogen concentration (parts per billion) and standard deviation at different time points (TLH, Lacer HaliTM treatment; PL, placebo; THA, HalitaTM treatment). *: Statistically significant results (p < 0.05) between the placebo and Lacer HaliTM groups were found. **: Statistically significant results (p < 0.05) between the Lacer HaliTM and HalitaTM groups were found.
Figure 4
Figure 4
Mean methyl mercaptan concentration (parts per billion) and standard deviation at different times (TLH, Lacer HaliTM treatment; PL, placebo; THA, HalitaTM treatment). There were no statistically significant results.
See this image and copyright information in PMC

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