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Review
. 2021 May 23;13(6):1780.
doi: 10.3390/nu13061780.

The Microbiome as a Therapy in Pouchitis and Ulcerative Colitis

Jean-Frédéric LeBlanc  1 , Jonathan P Segal  2 , Lucia Maria de Campos Braz  1   3 , Ailsa L Hart  1   3
Affiliations
Review

The Microbiome as a Therapy in Pouchitis and Ulcerative Colitis

Jean-Frédéric LeBlanc et al. Nutrients. .

Abstract

The gut microbiome has been implicated in a range of diseases and there is a rapidly growing understanding of this ecosystem's importance in inflammatory bowel disease. We are yet to identify a single microbe that causes either ulcerative colitis (UC) or pouchitis, however, reduced microbiome diversity is increasingly recognised in active UC. Manipulating the gut microbiome through dietary interventions, prebiotic and probiotic compounds and faecal microbiota transplantation may expand the therapeutic landscape in UC. Specific diets, such as the Mediterranean diet or diet rich in omega-3 fatty acids, may reduce intestinal inflammation or potentially reduce the risk of incident UC. This review summarises our knowledge of gut microbiome therapies in UC and pouchitis.

Keywords: ileoanal pouch inflammatory bowel disease; microbiota; ulcerative colitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The role of the gut microbiome.
Figure 2
Figure 2
Methods of manipulating the gut microbiota.
See this image and copyright information in PMC

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