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Review
. 2021 May 28;57(6):545.
doi: 10.3390/medicina57060545.

The Management of Prodromal Symptoms of Bipolar Disorder: Available Options and Future Perspectives

Elisa Del Favero  1 , Cristiana Montemagni  2 , Paola Bozzatello  1 , Claudio Brasso  1 , Cecilia Riccardi  1 , Paola Rocca  1   2
Affiliations
Review

The Management of Prodromal Symptoms of Bipolar Disorder: Available Options and Future Perspectives

Elisa Del Favero et al. Medicina (Kaunas). .

Abstract

The onset of prodromal symptoms in subjects who are at familial or clinical risk for bipolar disorder could be considered as an important alarm bell for the development of the disease and should be carefully detected. The management of prodromes in bipolar high-risk patients appears to be an important means of prevention; nevertheless, at the moment, there aren't clear and widely shared treatment indications. The aim of this review is to summarize the available treatment options (pharmacological, psychosocial and nutraceutical) for the management of prodromal symptoms in subjects who are at familial or clinical risk for bipolar disorder.

Keywords: bipolar disorder; early intervention; high risk; nutraceuticals; prodromes; psychiatry; psychopharmacology; psychotherapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart according to the PRISMA Statement [34].
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References

    1. World Health Organization . Update of the Mental Health Gap Action Programme (mhGAP) Guidelines for Mental, Neurological and Substance Use Disorders. WHO; Geneva, Switzerland: 2015. - PubMed
    1. Axelson D., Goldstein B., Goldstein T., Monk K., Yu H., Hickey M.B., Sakolsky D., Diler R., Hafeman D., Merranko J., et al. Diagnostic precursors to bipolar disorder in offspring of parents with bipolar disorder: A longitudinal study. Am. J. Psychiatry. 2015;172:638–646. doi: 10.1176/appi.ajp.2014.14010035. - DOI - PMC - PubMed
    1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders (DSM-5®) American Psychiatric Publishing; Washington, DC, USA: 2013.
    1. Weintraub M.J., Schneck C.D., Walshaw P.D., Chang K.D., Sullivan A.E., Singh M.K., Miklowitz D.J. Longitudinal trajectories of mood symptoms and global functioning in youth at high risk for bipolar disorder. J. Affect. Disord. 2020;277:394–401. doi: 10.1016/j.jad.2020.08.018. - DOI - PMC - PubMed
    1. Birmaher B., Axelson D., Goldstein B., Monk K., Kalas C., Obreja M., Hickey M.B., Iyengar S., Brent D., Shamseddeen W., et al. Psychiatric disorders in preschool offspring of parents with bipolar disorder: The Pittsburgh Bipolar Offspring Study (BIOS) Am. J. Psychiatry. 2010;167:321–330. doi: 10.1176/appi.ajp.2009.09070977. - DOI - PMC - PubMed