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Review
. 2021 May 27;22(11):5722.
doi: 10.3390/ijms22115722.

Role of Physical Exercise and Nutraceuticals in Modulating Molecular Pathways of Osteoarthritis

Alessandro de Sire  1 , Nicola Marotta  1 , Cinzia Marinaro  1 , Claudio Curci  2 , Marco Invernizzi  3   4 , Antonio Ammendolia  1
Affiliations
Review

Role of Physical Exercise and Nutraceuticals in Modulating Molecular Pathways of Osteoarthritis

Alessandro de Sire et al. Int J Mol Sci. .

Abstract

Osteoarthritis (OA) is a painful and disabling disease that affects millions of patients. Its etiology is largely unknown, but it is most likely multifactorial. OA pathogenesis involves the catabolism of the cartilage extracellular matrix and is supported by inflammatory and oxidative signaling pathways and marked epigenetic changes. To delay OA progression, a wide range of exercise programs and naturally derived compounds have been suggested. This literature review aims to analyze the main signaling pathways and the evidence about the synergistic effects of these two interventions to counter OA. The converging nutrigenomic and physiogenomic intervention could slow down and reduce the complex pathological features of OA. This review provides a comprehensive picture of a possible signaling approach for targeting OA molecular pathways, initiation, and progression.

Keywords: aging; dietary supplements; exercise; inflammaging; inflammation; nutraceuticals; osteoarthritis; physical activity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Involvement of nutraceuticals and exercise in molecular pathways for apoptotic, pro-, or anti-inflammatory signaling.
See this image and copyright information in PMC

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