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Review
. 2021 May 31;26(11):3311.
doi: 10.3390/molecules26113311.

Advances in the Study of Metabolomics and Metabolites in Some Species Interactions

Affiliations
Review

Advances in the Study of Metabolomics and Metabolites in Some Species Interactions

Rui Liu et al. Molecules. .

Abstract

In the natural environment, interactions between species are a common natural phenomena. The mechanisms of interaction between different species are mainly studied using genomic, transcriptomic, proteomic, and metabolomic techniques. Metabolomics is a crucial part of system biology and is based on precision instrument analysis. In the last decade, the emerging field of metabolomics has received extensive attention. Metabolomics not only provides a qualitative and quantitative method for studying the mechanisms of interactions between different species, but also helps clarify the mechanisms of defense between the host and pathogen, and to explore new metabolites with various biological activities. This review focuses on the methods and progress of interspecies metabolomics. Additionally, the prospects and challenges of interspecies metabolomics are discussed.

Keywords: analysis technologies; interactions; metabolites; metabolomics; species.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The workflow of discovering differential compounds by the LC-MS-based metabolomic method.
Figure 2
Figure 2
The structures of metabolites 1–28.
Figure 3
Figure 3
Interactions among Fusarium verticillioides, Ustilago maydis, and Zea mays.
Figure 4
Figure 4
Interactions among Paraconiothyrium variabile, Fusarium oxysporum, and Cephalotaxus harringtonia.

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References

    1. Raamsdonk L.M., Teusink B., Broadhurst D., Zhang N., Hayes A., Walsh M.C., Berden J.A., Brindle K.M., Kell D.B., Rowland J.J., et al. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat. Biotechnol. 2001;19:45–50. doi: 10.1038/83496. - DOI - PubMed
    1. Palsson B. Metabolic systems biology. FEBS Lett. 2009;583:3900–3904. doi: 10.1016/j.febslet.2009.09.031. - DOI - PMC - PubMed
    1. Oliver S.G., Winson M.K., Kell D.B., Baganz F. Systematic functional analysis of the yeast genome. Trends Biotechnol. 1998;16:373–378. doi: 10.1016/S0167-7799(98)01214-1. - DOI - PubMed
    1. Fiehn O. Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Comp. Funct. Genom. 2001;2:155–168. doi: 10.1002/cfg.82. - DOI - PMC - PubMed
    1. Ryan D., Robards K. Metabolomics the greatest omics of them all. Anal. Chem. 2006;78:7954–7958. doi: 10.1021/ac0614341. - DOI - PubMed

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