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. 2021 May 31;11(6):510.
doi: 10.3390/life11060510.

Genomic Regions and Candidate Genes Linked to Capped Hock in Pig

Lyubov Getmantseva  1 , Maria Kolosova  1   2 , Faridun Bakoev  1 , Anna Zimina  1 , Siroj Bakoev  1   3
Affiliations

Genomic Regions and Candidate Genes Linked to Capped Hock in Pig

Lyubov Getmantseva et al. Life (Basel). .

Abstract

Capped hock affects the exterior of pedigree pigs, making them unsalable and resulting in a negative impact on the efficiency of pig-breeding centers. The purpose of this paper was to carry out pilot studies aimed at finding genomic regions and genes linked to the capped hock in pigs. The studies were carried out on Landrace pigs (n = 75) and Duroc pigs (n = 70). To identify genomic regions linked to capped hock in pigs, we used smoothing FST statistics. Genotyping was performed with GeneSeek® GGP Porcine HD Genomic Profiler v1 (Illumina Inc, USA). The research results showed 70 SNPs linked to capped hock in Landrace (38 SNPs) and Duroc (32 SNPs). The identified regions overlapped with QTLs related with health traits (blood parameters) and meat and carcass traits (fatness). In total, 31 genes were identified (i.e., 17 genes in Landrace, 14 genes in Durocs). Three genes appeared in both the Landrace and Duroc groups, including A2ML1 (SSC5), ROBO2 (SSC13), and MSI1 (SSC14). We identified genomic regions directly or indirectly linked to capped hock, which thus might contribute to identifying genetic variants and using them as genetic markers in pig breeding.

Keywords: A2ML1; MSI1; ROBO2; candidate genes; capped hock; genome; pig; selection signatures.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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