Methylation and Noncoding RNAs in Gastric Cancer: Everything Is Connected

doi:10.3390/ijms22115683

Review

. 2021 May 26;22(11):5683.

doi: 10.3390/ijms22115683.

Methylation and Noncoding RNAs in Gastric Cancer: Everything Is Connected

Irina V Bure¹, Marina V Nemtsova^{1

2}

Affiliations

¹ Laboratory of Medical Genetics, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
² Laboratory of Epigenetics, Research Centre for Medical Genetics, 115522 Moscow, Russia.

PMID: 34073603
PMCID: PMC8199097
DOI: 10.3390/ijms22115683

Review

Methylation and Noncoding RNAs in Gastric Cancer: Everything Is Connected

Irina V Bure et al. Int J Mol Sci. 2021.

. 2021 May 26;22(11):5683.

doi: 10.3390/ijms22115683.

Authors

Irina V Bure¹, Marina V Nemtsova^{1

2}

Affiliations

¹ Laboratory of Medical Genetics, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
² Laboratory of Epigenetics, Research Centre for Medical Genetics, 115522 Moscow, Russia.

PMID: 34073603
PMCID: PMC8199097
DOI: 10.3390/ijms22115683

Abstract

Despite recent progress, gastric cancer remains one of the most common cancers and has a high mortality rate worldwide. Aberrant DNA methylation pattern and deregulation of noncoding RNA expression appear in the early stages of gastric cancer. Numerous investigations have confirmed their significant role in gastric cancer tumorigenesis and their high potential as diagnostic and prognostic biomarkers. Currently, it is clear that these epigenetic regulators do not work alone but interact with each other, generating a complex network. The aim of our review was to summarize the current knowledge of this interaction in gastric cancer and estimate its clinical potential for the diagnosis, prognosis, and treatment of the disease.

Keywords: DNA methylation; biomarker; epigenetics; gastric cancer; noncoding RNAs.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
The interplay between DNA methylation and ncRNAs in GC epigenetic regulation. GC—gastric cancer; EMT—epithelial–mesenchymal transition; arrows—activation; bars—suppression.

See this image and copyright information in PMC

Cited by

Genome-wide DNA methylation profiling reveals a novel hypermethylated biomarker PRKCB in gastric cancer.
Li L, Fei X, Wang H, Chen S, Xu X, Ke H, Zhou Y, Hu Y, He C, Xie C, Lu N, Liu J, Zhu Y, Li N. Li L, et al. Sci Rep. 2024 Nov 4;14(1):26605. doi: 10.1038/s41598-024-78135-6. Sci Rep. 2024. PMID: 39496833 Free PMC article.
Cross Talks between Oxidative Stress, Inflammation and Epigenetics in Diabetic Retinopathy.
Kowluru RA. Kowluru RA. Cells. 2023 Jan 12;12(2):300. doi: 10.3390/cells12020300. Cells. 2023. PMID: 36672234 Free PMC article. Review.
A microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma.
Cai S, Zhang Y, Zhang X, Wang L, Wu Z, Fang W, Chen X. Cai S, et al. J Gastrointest Oncol. 2022 Apr;13(2):510-526. doi: 10.21037/jgo-22-137. J Gastrointest Oncol. 2022. PMID: 35557573 Free PMC article.
Mutual Regulation of ncRNAs and Chromatin Remodeling Complexes in Normal and Pathological Conditions.
Bure IV, Nemtsova MV. Bure IV, et al. Int J Mol Sci. 2023 Apr 25;24(9):7848. doi: 10.3390/ijms24097848. Int J Mol Sci. 2023. PMID: 37175555 Free PMC article. Review.
ENTPD1-AS1-miR-144-3p-mediated high expression of COL5A2 correlates with poor prognosis and macrophage infiltration in gastric cancer.
Yuan HM, Pu XF, Wu H, Wu C. Yuan HM, et al. World J Gastrointest Oncol. 2023 Jul 15;15(7):1182-1199. doi: 10.4251/wjgo.v15.i7.1182. World J Gastrointest Oncol. 2023. PMID: 37546560 Free PMC article.

See all "Cited by" articles

References

1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed
1. Sitarz R., Skierucha M., Mielko J., Offerhaus J., Maciejewski R., Polkowski W. Gastric cancer: Epidemiology, prevention, classification, and treatment. Cancer Manag. Res. 2018;10:239–248. doi: 10.2147/CMAR.S149619. - DOI - PMC - PubMed
1. Necula L., Matei L., Dragu D., Neagu A.I., Mambet C., Nedeianu S., Bleotu C., Diaconu C.C., Chivu-Economescu M. Recent advances in gastric cancer early diagnosis. World J. Gastroenterol. 2019;25:2029–2044. doi: 10.3748/wjg.v25.i17.2029. - DOI - PMC - PubMed
1. Zhou Z., Lin Z., Pang X., Tariq M.A., Ao X., Li P., Wang J. Epigenetic regulation of long non-coding RNAs in gastric cancer. Oncotarget. 2017;9:19443–19458. doi: 10.18632/oncotarget.23821. - DOI - PMC - PubMed
1. Maruyama R., Suzuki H., Yamamoto E., Imai K., Shinomura Y. Emerging links between epigenetic alterations and dysregulation of noncoding RNAs in cancer. Tumor Biol. 2012;33:277–285. doi: 10.1007/s13277-011-0308-9. - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

Grants and funding

20-75-10117/Russian Science Foundation

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed

[2] Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed

[3] Sitarz R., Skierucha M., Mielko J., Offerhaus J., Maciejewski R., Polkowski W. Gastric cancer: Epidemiology, prevention, classification, and treatment. Cancer Manag. Res. 2018;10:239–248. doi: 10.2147/CMAR.S149619. - DOI - PMC - PubMed

[4] Sitarz R., Skierucha M., Mielko J., Offerhaus J., Maciejewski R., Polkowski W. Gastric cancer: Epidemiology, prevention, classification, and treatment. Cancer Manag. Res. 2018;10:239–248. doi: 10.2147/CMAR.S149619. - DOI - PMC - PubMed

[5] Necula L., Matei L., Dragu D., Neagu A.I., Mambet C., Nedeianu S., Bleotu C., Diaconu C.C., Chivu-Economescu M. Recent advances in gastric cancer early diagnosis. World J. Gastroenterol. 2019;25:2029–2044. doi: 10.3748/wjg.v25.i17.2029. - DOI - PMC - PubMed

[6] Necula L., Matei L., Dragu D., Neagu A.I., Mambet C., Nedeianu S., Bleotu C., Diaconu C.C., Chivu-Economescu M. Recent advances in gastric cancer early diagnosis. World J. Gastroenterol. 2019;25:2029–2044. doi: 10.3748/wjg.v25.i17.2029. - DOI - PMC - PubMed

[7] Zhou Z., Lin Z., Pang X., Tariq M.A., Ao X., Li P., Wang J. Epigenetic regulation of long non-coding RNAs in gastric cancer. Oncotarget. 2017;9:19443–19458. doi: 10.18632/oncotarget.23821. - DOI - PMC - PubMed

[8] Zhou Z., Lin Z., Pang X., Tariq M.A., Ao X., Li P., Wang J. Epigenetic regulation of long non-coding RNAs in gastric cancer. Oncotarget. 2017;9:19443–19458. doi: 10.18632/oncotarget.23821. - DOI - PMC - PubMed

[9] Maruyama R., Suzuki H., Yamamoto E., Imai K., Shinomura Y. Emerging links between epigenetic alterations and dysregulation of noncoding RNAs in cancer. Tumor Biol. 2012;33:277–285. doi: 10.1007/s13277-011-0308-9. - DOI - PubMed

[10] Maruyama R., Suzuki H., Yamamoto E., Imai K., Shinomura Y. Emerging links between epigenetic alterations and dysregulation of noncoding RNAs in cancer. Tumor Biol. 2012;33:277–285. doi: 10.1007/s13277-011-0308-9. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Methylation and Noncoding RNAs in Gastric Cancer: Everything Is Connected

Affiliations

Methylation and Noncoding RNAs in Gastric Cancer: Everything Is Connected

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Medical