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Review
. 2021 May 24;22(11):5514.
doi: 10.3390/ijms22115514.

An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS)

Francesca Truzzi  1 , Camilla Tibaldi  1 , Yanxin Zhang  1 , Giovanni Dinelli  1 , Eros D Amen  1
Affiliations
Review

An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS)

Francesca Truzzi et al. Int J Mol Sci. .

Abstract

Polyphenols are natural organic compounds produced by plants, acting as antioxidants by reacting with ROS. These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavailability in humans. However, the digestion process of phenolic compounds is still not completely clear. Moreover, bioavailability is dependent on the metabolic phase of these compounds. The LogP value can be managed as a simplified measure of the lipophilicity of a substance ingested within the human body, which affects resultant absorption. The biopharmaceutical classification system (BCS), a method used to classify drugs intended for gastrointestinal absorption, correlates the solubility and permeability of the drug with both the rate and extent of oral absorption. BCS may be helpful to measure the bioactive constituents of foods, such as polyphenols, in order to understand their nutraceutical potential. There are many literature studies that focus on permeability, absorption, and bioavailability of polyphenols and their resultant metabolic byproducts, but there is still confusion about their respective LogP values and BCS classification. This review will provide an overview of the information regarding 10 dietarypolyphenols (ferulic acid, chlorogenic acid, rutin, quercetin, apigenin, cirsimaritin, daidzein, resveratrol, ellagic acid, and curcumin) and their association with the BCS classification.

Keywords: LogP; bioavailability; biopharmaceutical classification system; metabolism; polyphenols.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Dietary polyphenols known subclasses scheme.
Figure 2
Figure 2
Principle metabolic steps of dietary phenolic compound (PC) in humans.
See this image and copyright information in PMC

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