Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May 24;22(11):5539.
doi: 10.3390/ijms22115539.

Migraine and Sleep-An Unexplained Association?

Marta Waliszewska-Prosół  1 , Marta Nowakowska-Kotas  1 , Justyna Chojdak-Łukasiewicz  1 , Sławomir Budrewicz  1
Affiliations
Review

Migraine and Sleep-An Unexplained Association?

Marta Waliszewska-Prosół et al. Int J Mol Sci. .

Abstract

Migraine and sleep disorders are common chronic diseases in the general population, with significant negative social and economic impacts. The association between both of these phenomena has been observed by clinicians for years and is confirmed by many epidemiological studies. Despite this, the nature of this relationship is still not fully understood. In recent years, there has been rapid progress in understanding the common anatomical structures of and pathogenetic mechanism between sleep and migraine. Based on a literature review, the authors present the current view on this topic as well as ongoing research in this field, with reference to the key points of the biochemical and neurophysiological processes responsible for both these disorders. In the future, a better understanding of these mechanisms will significantly expand the range of treatment options.

Keywords: dopamine; melatonin; migraine; orexins; serotonin; sleep; sleep disorders.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. GBD 2016 Disease and Injury Incidence and Prevalence Collaborators Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390:1211–1259. doi: 10.1016/S0140-6736(17)32154-2. - DOI - PMC - PubMed
    1. Ashina M. Migraine. N. Engl. J. Med. 2020;383:1866–1876. doi: 10.1056/NEJMra1915327. - DOI - PubMed
    1. Lipton R.B., Munjal S., Alam Mbbs M.A., Buse D.C., Fanning K.M., Reed M.L., Schwedt T.J., Dodick D.W. Migraine in America Symptoms and Treatment (MAST) Study: Baseline Study Methods, Treatment Patterns, and Gender Differences. Headache J. Head Face Pain. 2018;58:1408–1426. doi: 10.1111/head.13407. - DOI - PubMed
    1. Olesen J. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38:1–211. - PubMed
    1. Dodick D.W. Migraine. Lancet. 2018;391:1315–1330. doi: 10.1016/S0140-6736(18)30478-1. - DOI - PubMed

MeSH terms