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Review
. 2021 May 24;22(11):5539.
doi: 10.3390/ijms22115539.

Migraine and Sleep-An Unexplained Association?

Marta Waliszewska-Prosół  1 , Marta Nowakowska-Kotas  1 , Justyna Chojdak-Łukasiewicz  1 , Sławomir Budrewicz  1
Affiliations
Review

Migraine and Sleep-An Unexplained Association?

Marta Waliszewska-Prosół et al. Int J Mol Sci. .

Abstract

Migraine and sleep disorders are common chronic diseases in the general population, with significant negative social and economic impacts. The association between both of these phenomena has been observed by clinicians for years and is confirmed by many epidemiological studies. Despite this, the nature of this relationship is still not fully understood. In recent years, there has been rapid progress in understanding the common anatomical structures of and pathogenetic mechanism between sleep and migraine. Based on a literature review, the authors present the current view on this topic as well as ongoing research in this field, with reference to the key points of the biochemical and neurophysiological processes responsible for both these disorders. In the future, a better understanding of these mechanisms will significantly expand the range of treatment options.

Keywords: dopamine; melatonin; migraine; orexins; serotonin; sleep; sleep disorders.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

References

    1. GBD 2016 Disease and Injury Incidence and Prevalence Collaborators Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390:1211–1259. doi: 10.1016/S0140-6736(17)32154-2. - DOI - PMC - PubMed
    1. Ashina M. Migraine. N. Engl. J. Med. 2020;383:1866–1876. doi: 10.1056/NEJMra1915327. - DOI - PubMed
    1. Lipton R.B., Munjal S., Alam Mbbs M.A., Buse D.C., Fanning K.M., Reed M.L., Schwedt T.J., Dodick D.W. Migraine in America Symptoms and Treatment (MAST) Study: Baseline Study Methods, Treatment Patterns, and Gender Differences. Headache J. Head Face Pain. 2018;58:1408–1426. doi: 10.1111/head.13407. - DOI - PubMed
    1. Olesen J. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38:1–211. - PubMed
    1. Dodick D.W. Migraine. Lancet. 2018;391:1315–1330. doi: 10.1016/S0140-6736(18)30478-1. - DOI - PubMed

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