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. 1988;14(1):48-51.

On the in vitro cytotoxicity of 1-chloroethyl-2-chloromethyl-2-imidazoline hydrochloride

J J Mircheva  1
Affiliations
  • PMID: 3407416

On the in vitro cytotoxicity of 1-chloroethyl-2-chloromethyl-2-imidazoline hydrochloride

J J Mircheva. Acta Physiol Pharmacol Bulg. 1988.

Abstract

The cytotoxic activity of the monofunctional alkylating agent 1-chloroethyl-2-chloromethyl-2-imidazoline hydrochloride (chlorimidazine), synthesized according to predetermined properties, is characterized. The data obtained show that the substance has a cell-cycle state nonspecific cytotoxic effect. The interaction of chlorimidazine with cellular DNA is traced. It is found that the substance does not induce a break in the macromolecule, apurine sites or intercalation. Ensuing from the chemical structure of the compound, the probable mechanism of its cytotoxic action is discussed.

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