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. 2022 Mar 25;158(6):251-259.
doi: 10.1016/j.medcli.2021.03.027. Epub 2021 May 7.

Susceptibility and risk of SARS-COV-2 infection among middle-aged and older adults in Tarragona area, Spain

[Article in English, Spanish]
Eva M Satué-Gracia  1 , Angel Vila-Córcoles  2 , Cinta de Diego-Cabanes  3 , Angel Vila-Rovira  4 , Cristina Torrente-Fraga  5 , Frederic Gómez-Bertomeu  6 , Imma Hospital-Guardiola  7 , Olga Ochoa-Gondar  8 , Francisco Martín-Luján  2
Affiliations

Susceptibility and risk of SARS-COV-2 infection among middle-aged and older adults in Tarragona area, Spain

[Article in English, Spanish]
Eva M Satué-Gracia et al. Med Clin (Barc). .

Abstract
in English, Spanish

Objective: To analyse susceptibility/risk of suffering COVID-19 among adults with distinct underlying medical conditions.

Methods: Population-based cohort study involving 79,083 individuals ≥50 years old in Tarragona (Southern Catalonia, Spain). Baseline cohort characteristics (demographic, pre-existing comorbidities, chronic medications and vaccinations history) were established at study start (01/03/2020) and primary outcome was laboratory-confirmed COVID-19 occurred among cohort members throughout 01/03/2020-30/06/2020. Risk of suffering COVID-19 was evaluated by Cox regression, estimating multivariable hazard ratios (HRs) adjusted for age/sex and pre-existing comorbidities.

Results: Across study period, 536 laboratory-confirmed COVID-19 cases were observed (mean incidence: 39.5 cases per 100,000 persons-week). In multivariable-analysis, increasing age/years (HR: 1.01; 95% CI: 1.00-1.02), nursing-home (HR: 20.19; 95% CI: 15.98-25.51), neurological disease (HR: 1.35; 95% CI: 1.03-1.77), taking diuretics (HR: 1.39; 95% CI: 1.10-1.75), antiplatelet (HR: 1.36; 95% CI: 1.05-1.76) and benzodiazepines (HR: 1.24; 95% CI: 1.00-1.53) increased risk; conversely, taking angiotensin-converting-enzyme inhibitors (HR: 0.78; 95% CI: 0.61-1.00), angiotensin-receptor-blockers (HR: 0.70; 95%CI: 0.51-0.96) and statins (HR: 0.75; 95% CI: 0.58-0.96) were associated with reduced risk. Among community-dwelling individuals, pre-existing cancer, renal and cardiac disease appeared also related with an increased risk, whereas influenza vaccination was associated with reduced risk.

Conclusion: In a setting with relatively low incidence of COVID-19 across the first wave of pandemic period, increasing age, nursing-home residence and multiple comorbidities appear predisposing for COVID-19 among middle-aged/older adults. Conversely, statins, angiotensin-receptor blockers/inhibitors and influenza vaccination were related with decreased risk.

Objetivo: Analizar incidencia y riesgo/susceptibilidad de sufrir la COVID-19 en adultos según distintas condiciones médicas preexistentes.

Métodos: Cohorte de base poblacional que incluyó 79.083 personas ≥50 años en Tarragona. Características basales de la cohorte (edad/sexo, comorbilidades, medicaciones crónicas) se establecieron a 01-03-2020 y se registraron todos los casos de COVID-19 confirmada ocurridos en miembros de la cohorte hasta el 30-06-2020. Para estimación de riesgos se realizó regresión de Cox, con cálculo de hazard ratio (HR) ajustados por edad, sexo y comorbilidad.

Resultados: Se observaron 536 casos confirmados de COVID-19 (incidencia media: 39,5 casos por 100.000 personas-semana). En análisis multivariante, edad/años (HR: 1,01; IC el 95%: 1,00-1,02; p = 0,050), estar institucionalizado/residencia (HR: 20,19; IC 95%: 15,98-25,51; p<0,001), enfermedad neurológica (HR: 1,35; IC el 95%: 1,03-1,77), diuréticos (HR: 1,39; IC 95%: 1,10-1,75), antiagregantes plaquetarios (HR: 1,36; IC 95%: 1,05-1,76) y benzodiacepinas (HR: 1,24; IC 95%: 1,00-1,53) se asociaron con un riesgo aumentado de la COVID-19 analizando la totalidad de la cohorte; contrariamente, medicación IECA (HR: 0,78; IC el 95%: 0,61-1,00), ARA-II (HR: 0,70; IC el 95%: 0,51-0,96) y estatinas (HR: 0,75; IC el 95%: 0,58-0,96) se asociaron con menor riesgo. Entre personas no institucionalizadas, cáncer, nefropatía y cardiopatía se asociaron con mayor riesgo y vacunación antigripal con menor riesgo.

Conclusión: En un área con relativamente baja incidencia de COVID-19, edad, institucionalización y múltiples comorbilidades aumentaron el riesgo/susceptibilidad de sufrir la COVID-19. Contrariamente, estatinas, inhibidores del sistema renina-angiotensina y vacunación antigripal se asociaron con menor riesgo.

Keywords: COVID-19; Coronavirus; Incidence; Incidencia; Riesgo; Risk; SARS-COV-2; SARS-CoV-2.

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Figures

Fig. 1
Fig. 1
Study scheme. PCC: primary care centres; ICS: Institut Castalà de la Salut; e-CAP: electronic primary care clinical records system; ICD. International classification of diseases, 10th revision; ATC: Anatomic & Therapeutic Classification for medications used.
Fig. 2
Fig. 2
Weekly distribution of COVID-19-confirmed cases across study period (March 1st–June 30th 2020).
See this image and copyright information in PMC

References

    1. World Health Organisation (WHO). Listings of WHO's response to COVID-19. Available from: https://www.who.int/news/item/29-06-2020-covidtimeline [accessed 20.1.21].
    1. World Health Organisation (WHO). Coronavirus Disease (COVID19). Weekly epidemiological update-27 January 2021. Available from: https://www.who.int/publications/m/item/weekly-epidemiological-update---... [accessed 28.1.21].
    1. Ministerio de Sanidad. Dirección General de Salud Pública. Centro de Coordinación de Alertas y Emergencias Sanitarias. Actualización n(300. Enfermedad por el coronavirus (COVID-19). 28.01.2021. Available from: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual... [accessed 28.1.21].
    1. Rodríguez-Molinero A., Gálvez-Barrón C., Miñarro A., Macho O., López G.F., Robles M.T., et al. COVID-19 Research Group of CSAPG Association between COVID-19 prognosis and disease presentation, comorbidities and chronic treatment of hospitalized patients. PLOS ONE. 2020;15:e0239571. doi: 10.1371/journal.pone.0239571. - DOI - PMC - PubMed
    1. Grasselli G., Zangrillo A., Zanella A., Antonelli M., Cabrini L., Castelli A., et al. COVID-19 Lombardy ICU Network. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323:1574–1581. doi: 10.1001/jama.2020.5394. - DOI - PMC - PubMed