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Review
. 2021 Aug 1;34(4):507-513.
doi: 10.1097/ACO.0000000000001028.

Prehospital administration of blood and plasma products

Anna Roehl  1 , Oliver Grottke
Affiliations
Review

Prehospital administration of blood and plasma products

Anna Roehl et al. Curr Opin Anaesthesiol. .

Abstract

Purpose of review: Posttraumatic bleeding following major trauma is life threatening for the patient and remains a major global health issue. Bleeding after major trauma is worsened by trauma-induced coagulopathy (TIC). TIC consists of acute trauma coagulopathy and resuscitation coagulopathy. The early diagnosis and management of prehospital TIC management are challenging.

Recent findings: Concepts for early diagnosis and management of civilian prehospital TIC management are evolving. The feasibility of prehospital blood component as well as coagulation factor transfusion has been proven.

Summary: Due to different national guidelines and regulations of blood component therapies there is a wide heterogeneity in concepts of prehospital damage control resuscitation. Tranexamic acid administration is widely accepted, whereas the transfusion of whole blood, blood components, or coagulations factors needs further examination in the civilian setting.

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References

    1. Schlimp CJ, Voelckel W, Inaba K, et al. Estimation of plasma fibrinogen levels based on hemoglobin, base excess and Injury Severity Score upon emergency room admission. Crit Care 2013; 17:R137.
    1. Holcomb JB, Tilley BC, Baraniuk S, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA 2015; 313:471–482.
    1. Lyon RM, de Sausmarez E, McWhirter E, et al. Prehospital transfusion of packed red blood cells in 147 patients from a UK helicopter emergency medical service. Scand J Trauma Resusc Emerg Med 2017; 25:12.
    1. Naumann DN, Hancox JM, Raitt J, et al. What fluids are given during air ambulance treatment of patients with trauma in the UK, and what might this mean for the future? Results from the RESCUER observational cohort study. BMJ Open 2018; 8:e019627.
    1. Vuorinen P, Kiili JE, Setala P, et al. Prehospital administration of blood products: experiences from a Finnish physician-staffed helicopter emergency medical service. BMC Emerg Med 2020; 20:55.

MeSH terms