Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Sep 1;78(3):361-371.
doi: 10.1097/FJC.0000000000001064.

Diagnosis and Treatment of Intracardiac Thrombus

Murti Patel  1 , Xin Wei  2 , Kylie Weigel  3 , Zachary M Gertz  2 , Jordana Kron  2 , Austin A Robinson  4 , Cory R Trankle  2
Affiliations
Review

Diagnosis and Treatment of Intracardiac Thrombus

Murti Patel et al. J Cardiovasc Pharmacol. .

Abstract

Intracardiac thrombi can occur in a variety of locations and are frequently encountered in clinical practice. Yet evidence-based guidance for clinicians managing patients with intracardiac thrombi is often limited. This review summarizes what is known regarding the prevalence of intracardiac thrombus, diagnostic strategies, clinical relevance, and treatment options, focusing on four specific types of thrombus for which recent research has shifted clinical understanding and treatment decisions: (1) left atrial appendage thrombus, (2) cardiac implantable electronic device lead thrombus, (3) bioprosthetic aortic valve thrombus, and (4) left ventricular thrombus. Additional studies, ideally prospective, randomized, and head-to-head in design, are needed to better inform best practices in patients with intracardiac thrombi.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest.

References

    1. Koupenova M, Kehrel BE, Corkrey HA, et al. Thrombosis and platelets: an update. Eur Heart J. 2017;38:785–791.
    1. Chernysh IN, Nagaswami C, Kosolapova S, et al. The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli. Sci Rep. 2020;10:5112.
    1. Stokes K, Chem B, Anderson J, et al. The encapsulation of polyurethane-insulated tranvenous cardiac pacemaker leads. Cardiovasc Pathol. 1995;4:163–171.
    1. Dangas GD, Weitz JI, Giustino G, et al. Prosthetic heart valve thrombosis. J Am Coll Cardiol. 2016;68:2670–2689.
    1. Zhan Y, Joza J, Al Rawahi M, et al. Assessment and management of the left atrial appendage thrombus in patients with nonvalvular atrial fibrillation. Can J Cardiol. 2018;34:252–261.

MeSH terms