Youth-onset type 2 diabetes: translating epidemiology into clinical trials
- PMID: 34075436
- DOI: 10.1007/s00125-021-05480-w
Youth-onset type 2 diabetes: translating epidemiology into clinical trials
Erratum in
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Correction to: Youth-onset type 2 diabetes: translating epidemiology into clinical trials.Diabetologia. 2021 Oct;64(10):2354. doi: 10.1007/s00125-021-05518-z. Diabetologia. 2021. PMID: 34309689 No abstract available.
Abstract
Globally, the proportion of new diagnoses of youth-onset diabetes represented by type 2 diabetes is increasing, and youth with type 2 diabetes commonly have complications and comorbidities, as well as a higher rate of mortality. In this review, we summarise what is known about the natural progression of youth-onset type 2 diabetes from published clinical trials and large-scale prospective epidemiological studies. It is important to note that the robust pathophysiological and treatment data specifically related to individuals with a diabetes onset at ≤20 years of age largely hails from the USA. Youth-onset type 2 diabetes is characterised by pathophysiological heterogeneity and inadequate glycaemic control, highlighting the need for new treatment approaches and innovative study designs in populations of varied genetic and cultural backgrounds.
Keywords: Clinical trials; Epidemiological studies; Review; Study design; Youth-onset type 2 diabetes.
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