Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May;48(5):4351-4360.
doi: 10.1007/s11033-021-06450-6. Epub 2021 Jun 2.

Circulating miRNA 27a and miRNA150-5p; a noninvasive approach to endometrial carcinoma

Rasha Abdelmawla Ghazala  1 , Eman Ahmed El-Attar  2 , Ziad Sami Abouzeid  3
Affiliations

Circulating miRNA 27a and miRNA150-5p; a noninvasive approach to endometrial carcinoma

Rasha Abdelmawla Ghazala et al. Mol Biol Rep. 2021 May.

Abstract

The search for novel non-invasive biomarkers such as epigenetic molecular markers is new hope for common and burdensome cancers. We aim to assess serum expression of miRNA 27a and miRNA150-5p in endometrial cancer patients. Serum was drawn for 36 un-intervened endometrial cancer patients scheduled for hysterectomy and 35 controls. miRNA 27a and miRNA150-5p were measured by real time reverse transcription polymerase chain reaction. Significant overexpression of both miRNA in patients (p < 0.001). At cutoffs 0.2872 & > 1.02, miRNA 27a showed 100% sensitivity, specificity, positive and negative predictive values. miRNA150-5p showed 88.89% sensitivity, 100% specificity, 100% positive and 78.9% negative predictive values. Areas under curve were 1.0 for miRNA 27a, 0.982 for miRNA 150 performing much better than Ca125. miRNA 27a was significantly associated with type I endometroid endometrial cancer. Conclusion: miRNA 27a and miRNA-150-5P can be suggested as promising biomarkers of endometrial cancer possibly part of a miRNA panel for management.

Keywords: Ca125; Endometrial carcinoma; Epigenetics; miRNA 27a; miRNA15-5p.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68:7–30. https://doi.org/10.3322/caac.21442 - DOI - PubMed - PMC
    1. Smith RA, Andrews KS, Brooks D et al (2018) Cancer screening in the United States, 2018: a review of current American cancer society guidelines and current issues in cancer screening. CA Cancer J Clin 68:297–316. https://doi.org/10.3322/caac.21446 - DOI - PubMed
    1. Reddy KB (2015) MicroRNA (miRNA) in cancer. Cancer Cell Int 15:38. https://doi.org/10.1186/s12935-015-0185-1 - DOI - PubMed - PMC
    1. Zhu H, Fan GC (2011) Extracellular/circulating microRNAs and their potential role in cardiovascular disease. Am J Cardiovasc Dis 1:138–149 - PubMed - PMC
    1. Lund E, Dahlberg JE (2006) Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs. Cold Spring Harb Symp Quant Biol 71:59–66. https://doi.org/10.1101/sqb.2006.71.050 - DOI - PubMed

MeSH terms

LinkOut - more resources