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Meta-Analysis
. 2021 Oct;34(5):1479-1489.
doi: 10.1007/s40620-021-01021-1. Epub 2021 Jun 2.

The global incidence and mortality of contrast-associated acute kidney injury following coronary angiography: a meta-analysis of 1.2 million patients

Zhubin Lun #  1   2   3 , Liwei Liu #  1 , Guanzhong Chen #  1 , Ming Ying #  1 , Jin Liu #  1 , Bo Wang  1 , Jingjing Liang  4 , Yongquan Yang  1 , Shiqun Chen  1 , Yibo He  1 , Edmund Y M Chung  5   6 , Jiyan Chen  1 , Jianfeng Ye  7 , Yong Liu  8
Affiliations
Meta-Analysis

The global incidence and mortality of contrast-associated acute kidney injury following coronary angiography: a meta-analysis of 1.2 million patients

Zhubin Lun et al. J Nephrol. 2021 Oct.

Erratum in

Abstract

Background: Contrast-associated acute kidney injury (CA-AKI) is a common complication after coronary angiography (CAG), which brings a poor prognosis. But up to now, there were fewer studies to discuss the incidence of CA-AKI comprehensively. We comprehensively explore the incidence of CA-AKI after coronary angiography.

Methods: We searched Medline, Embase, and Cochrane Database of Systematic Reviews (to 30th June 2019). We evaluated the world's incidence of the CA-AKI, and associated mortality, and to described geographic variations according to countries, regions, and economies. CA-AKI was defined as an increase in serum creatinine ≥ 0.5 mg/dl or ≥ 25% within 72 h. Random effects model meta-analyses and meta-regressions was performed to derive the sources of heterogeneity.

Results: A total of 134 articles (1,211,106 participants) were included in our meta-analysis. Most studies originated from China, Japan, Turkey and United States, from upper middle income and high income countries. The pooled incidence of CA-AKI after coronary angiography was 12.8% (95% CI 11.7-13.9%), and the CA-AKI associated mortality was 20.2% (95% CI 10.7-29.7%). The incidence of CA-AKI and the CA-AKI associated mortality were not declined over time (Incidence rate change: 0.23% 95% CI - 0.050 to 0.510 p = 0.617; Mortality rate change: - 1.05% 95% CI - 3.070 to 0.970 p = 0.308, respectively).

Conclusion: CA-AKI was a universal complication in many regions, and the burden of CA-AKI remains severe. In clinical practice, physicians should pay more attention to the occurrence and active prevention and treatment of CA-AKI.

Keywords: Contrast-associated acute kidney injury; Coronary angiography; Incidence; Meta-analysis; Mortality.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
Literature search and selection
Fig. 2
Fig. 2
Pooled incidence rate and mortality of CA-AKI by world zones. CA-AKI: increase in serum creatinine ≥ 0.5 mg/dl or ≥ 25% from baseline within 72 h after exposure to contrast
Fig. 3
Fig. 3
Funnel plot of standard error. CA-AKI: increase in serum creatinine ≥ 0.5 mg/dl or ≥ 25% from baseline within 72 h after exposure to contrast
See this image and copyright information in PMC

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