Correlation between lncRNA H19 rs2839698 polymorphism and susceptibility to NK / T cell lymphoma in Chinese population

Abstract

Purpose: Gene polymorphism has a potential influence cancer susceptibility. This study aimed to explore the role of lncRNA H19 rs2839698 polymorphism and its genotypes in influencing NK/T cell lymphoma (NKTCL) in Chinese population.

Methods: NKTCL patients (n=573) and healthy participants (n=688) were recruited. Their blood samples were collected for detecting H19 rs2839698 polymorphism and its genotypes using PCR-RFLP. The correlations of H19 rs2839698 polymorphism with NKTCL susceptibility and pathological indexes were analyzed by logistic regression analysis.

Results: No significant differences in age, body mass index (BMI), smoking, drinking and family history of cancer were detected between NKTCL patients and healthy participants. Hypertension and diabetes were statistically significant between groups. H19 rs2839698 polymorphism and its genotypes were correlated with NKTCL susceptibility. Moreover, compared with NKTCL patients carrying GG allele, patients carrying AG, AA and AG+AA alleles had more advanced tumor stage and higher incidence of EBV(+) and original involvement of non-paranasal structure.

Conclusions: LncRNA H19 rs2839698 polymorphism and its genotypes are correlated with NKTCL susceptibility.