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Comment
. 2021 Jun 1;33(6):1073-1075.
doi: 10.1016/j.cmet.2021.05.004.

A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion

Patrice D Cani  1 , Claude Knauf  2
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A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion

Patrice D Cani et al. Cell Metab. .
Free article

Abstract

Akkermansia muciniphila is a gut commensal known to improve host metabolism. The outer membrane protein Amuc_1100 has been shown to partially replicate these beneficial effects. Here, Yoon et al. (2021) have identified a novel protein (P9) secreted by A. muciniphila that stimulates GLP-1 secretion, thereby adding new insight to the biomolecule era to treat metabolic diseases.

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Conflict of interest statement

Declaration of interests P.D.C. is the inventor on patent applications dealing with the use of A. muciniphila and its components in the treatment of metabolic disorders. P.D.C. is co-founder of A-Mansia Biotech SA. P.D.C. and C.K. are co-founders of Enterosys S.A. (Labège, France).

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