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. 2021 Oct:138:219-226.
doi: 10.1016/j.jclinepi.2021.05.018. Epub 2021 May 30.

Methodology over metrics: current scientific standards are a disservice to patients and society

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Methodology over metrics: current scientific standards are a disservice to patients and society

Ben Van Calster et al. J Clin Epidemiol. 2021 Oct.

Abstract

Covid-19 research made it painfully clear that the scandal of poor medical research, as denounced by Altman in 1994, persists today. The overall quality of medical research remains poor, despite longstanding criticisms. The problems are well known, but the research community fails to properly address them. We suggest that most problems stem from an underlying paradox: although methodology is undeniably the backbone of high-quality and responsible research, science consistently undervalues methodology. The focus remains more on the destination (research claims and metrics) than on the journey. Notwithstanding, research should serve society more than the reputation of those involved. While we notice that many initiatives are being established to improve components of the research cycle, these initiatives are too disjointed. The overall system is monolithic and slow to adapt. We assert that top-down action is needed from journals, universities, funders and governments to break the cycle and put methodology first. These actions should involve the widespread adoption of registered reports, balanced research funding between innovative, incremental and methodological research projects, full recognition and demystification of peer review, improved methodological review of reports, adherence to reporting guidelines, and investment in methodological education and research. Currently, the scientific enterprise is doing a major disservice to patients and society.

Keywords: Methodology; Reporting; Research quality.

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Comment in

  • Methodology over metrics: Response to Van Calster et al.
    Bunce C, Hewison J, Teare MD, Al-Janabi H, Bonnett L, Hulme C, Kanaan M, Mitchell E, Peters T, Wason J, Williamson P. Bunce C, et al. J Clin Epidemiol. 2022 Mar;143:254. doi: 10.1016/j.jclinepi.2021.11.008. Epub 2021 Dec 3. J Clin Epidemiol. 2022. PMID: 34864202 No abstract available.

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References

    1. Glasziou PP, Sanders S, Hoffmann T. Waste in covid-19 research. BMJ. 2020;369:m1847. - PubMed
    1. Schwab S, Held L. Science after Covid-19: faster, better, stronger? Significance. 2020;4:8–9. - PMC - PubMed
    1. Wynants L, Van Calster B, Collins GS, Riley RD, Heinze G, Schuit E, et al. Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal. BMJ. 2020;369:m1328. - PMC - PubMed
    1. Alexander PE, Debono VB, Mammen MJ, Iorio A, Aryal K, Deng D, et al. COVID-19 coronavirus research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine. J Clin Epidemiol. 2020;123:120–126. - PMC - PubMed
    1. Chalmers I, Glasziou P. Avoidable waste in the production and reporting of research evidence. Lancet. 2009;374:86–89. - PubMed

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