Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug:236:12-19.
doi: 10.1016/j.imlet.2021.05.006. Epub 2021 May 30.

B cells as target for immunotherapy in rheumatic diseases - current status

Ewa Bryl  1
Affiliations
Review

B cells as target for immunotherapy in rheumatic diseases - current status

Ewa Bryl. Immunol Lett. 2021 Aug.

Abstract

This mini-review is a short overview of different therapeutical strategies targeting B cells in systemic autoimmune rheumatic diseases, mainly: rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and primary Sjogren Syndrome (pSS). Many strategies and their rationale are discussed in this review: B cells' depletion (anti-CD20, anti-CD22), long-lived plasma cells depletion (anti-CD19, anti-CD27, anti-CD38 and anti-CD138), changing activation of B cells (anti-BAFF) and inhibiting proteasomes in plasma cells (bortezomib). The past successful therapies and less successful are shown, and the possible reasons for failures are discussed.

Keywords: Anti-B cells therapy; Autoimmunity; Plasma cells; RA; SLE; pSS.

PubMed Disclaimer

LinkOut - more resources