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. 2021 Jun;43(6):429-435.
doi: 10.1055/s-0041-1730288. Epub 2021 Jun 2.

Evaluation of the Blood Level of Adiponectin in Pregnant Adolescents

Elaine Cristina Rocha Pádua  1 , Silvia Daher  1 , Isa de Pádua Cintra Sampaio  2 , Edward Araujo Júnior  1 , Cristina Falbo Guazzelli  1
Affiliations

Evaluation of the Blood Level of Adiponectin in Pregnant Adolescents

Elaine Cristina Rocha Pádua et al. Rev Bras Ginecol Obstet. 2021 Jun.

Abstract
in English, Portuguese

Objective: To evaluate serum levels of adiponectin in pregnant adolescents between 30 and 36 weeks of gestation.

Method: A prospective cross-sectional study enrolled 67 normal pregnant women between 30 and 36 weeks of gestation and eutrophic (body mass index [BMI]: 18.5-25 kg/m2), of which 36 were adolescents (< 20 years old) and 31 adults (≥ 20 years old). Serum adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). The t-student or Mann-Whitney tests were used for intergroup comparison.

Results: Pregnant adolescents showed significantly higher serum adiponectin concentrations compared with pregnant adults (p = 0.04). No differences were observed in adiponectin levels in younger pregnant adolescents (< 16 years old) compared with older pregnant adolescents (≥ 16 years old). Adiponectin values were divided into 3 subgroups: < 3,000 ng/mL, between 3,000 and 5,000 ng/mL, and > 5,000 ng/mL. Birthweight was significantly higher in women > 5,000 ng/mL when compared with < 3,000 ng/mL in the adolescent group. No association between pregestational adiponectin levels and BMI, gestational weight gain, and gestational age was observed; however, there was a positive relation with birthweight (p = 0.0239).

Conclusion: Serum adiponectin values in pregnant adolescents between 30 and 36 weeks of gestation were higher compared with pregnant adults; however, no differences between younger and older pregnant adolescents were observed.

Objetivo: Avaliar os níveis séricos de adiponectina em gestantes adolescentes entre 30 e 36 semanas de gestação. MéTODOS: Estudo prospectivo e transversal incluindo 67 gestantes normais entre 30 a 36 semanas e eutróficas (índice de massa corporal [IMC]: 18,5–25 kg/m2), sendo 36 adolescentes (< 20 anos) e 31 adultas (≥ 20 anos). Os níveis séricos de adiponectina foram avaliados por teste imunoenzimático (ELISA, na sigla em inglês). Para a comparação entre os grupos, utilizou-se os testes t-Student ou Mann-Whitney.

Resultados: As gestantes adolescentes apresentaram significativamente maiores concentrações séricas de adiponectina do que as adultas (p = 0,04). Não houve diferenças nos níveis de adiponectina quando comparadas as gestantes adolescentes precoces (< 16 anos) às tardias (≥ 16 anos). Os valores de adiponectina foram subdivididos em 3 grupos: < 3.000 ng/mL, entre 3.000 e 5.000 ng/mL e > 5.000 ng/mL. O peso do recém-nascido foi significantemente maior nas mulheres com > 5.000 ng/mL, quando comparadas as com < 3.000 ng/mL no grupo das adolescentes. Não foi observada associação entre os níveis de adiponectina e o IMC pré-gestacional, ganho de peso gestacional e a idade gestacional, porém houve relação positiva com o peso do recém-nascido (p = 0,0239). CONCLUSãO: Os valores séricos de adiponectina em gestantes adolescentes entre 30 e 36 semanas de gestação foram maiores do que os das gestantes adultas; contudo, sem diferenças entre gestantes adolescentes precoces e tardias.

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Conflict of interest statement

The authors have no conflict of interests to declare.

Figures

Fig. 1
Fig. 1
Flow chart of the selection of pregnant adolescents.
Fig. 2
Fig. 2
Serum adiponectin levels in pregnant adolescents ( n  = 36) and adults ( n  = 31) § Welch's adjusted t- Student Test.
See this image and copyright information in PMC

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