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Review
. 2021 Jun;43(6):474-479.
doi: 10.1055/s-0041-1730291. Epub 2021 Jun 2.

SARS-CoV-2 Infection and Placental Pathology

Caio Ribeiro Vieira Leal  1 , Rayra Amana Macêdo Maciel  1 , Mário Dias Corrêa Júnior  1
Affiliations
Review

SARS-CoV-2 Infection and Placental Pathology

Caio Ribeiro Vieira Leal et al. Rev Bras Ginecol Obstet. 2021 Jun.

Abstract
in English, Portuguese

Placental pathophysiology in SARS-CoV-2 infection can help researchers understand more about the infection and its impact on the maternal/neonatal outcomes. This brief review provides an overview about some aspects of the placental pathology in SARS-CoV-2 infection. In total, 11 papers were included. The current literature suggests that there are no specific histopathological characteristics in the placenta related to SARS-CoV-2 infection, but placentas from infected women are more likely to show findings of maternal and/or fetal malperfusion. The most common findings in placentas from infected women were fibrin deposition and intense recruitment of inflammatory infiltrates. The transplacental transmission of this virus is unlikely to occur, probably due to low expression of the receptor for SARS-CoV-2 in placental cell types. Further studies are needed to improve our knowledge about the interaction between the virus and the mother-fetus dyad and the impact on maternal and neonatal/fetal outcomes.

A fisiopatologia da placenta na infecção por SARS-CoV-2 pode ajudar os pesquisadores a entender mais sobre a infecção e seu impacto nos resultados maternos/neonatais. Esta revisão breve fornece uma visão geral sobre alguns aspectos da patologia placentária na infecção por SARS-CoV-2. Ao todo, 11 artigos foram incluídos. A literatura atual sugere que não há características histopatológicas específicas nas placentas relacionadas à infecção por SARS-CoV-2, mas as placentas de mulheres infectadas têm maior probabilidade de apresentar achados de má perfusão materna e/ou fetal. Os achados mais comuns em placentas de mulheres infectadas foram deposição de fibrina e intenso recrutamento de infiltrado inflamatório. A transmissão transplacentária deste vírus é improvável, devido à baixa expressão do receptor para SARS-CoV-2 em tipos de células da placenta. Mais estudos são necessários para melhorar nosso conhecimento sobre a interação entre o vírus e a díade mãe-feto e o impacto nos resultados maternos e neonatais/fetais.

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Conflict of interest statement

The authors have no conflict of interests to declare.

References

    1. World Health Organization WHO Coronavirus Disease (COVID-19) Dashboard [Internet]. 2020[cited 2020 Oct 12]. Available from:https://covid19.who.int/
    1. Petrilli C M, Jones S A, Yang J, Rajagopalan H, O'Donnell L, Chernyak Y et al.Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020;369:m1966. doi: 10.1136/bmj.m1966. - DOI - PMC - PubMed
    1. sixth batch of Anhui medical team aiding Wuhan for COVID-19 . Qiancheng X, Jian S, Lingling P, Lei H, Xiaogan J, Weihua L et al.Coronavirus disease 2019 in pregnancy. Int J Infect Dis. 2020;95:376–383. doi: 10.1016/j.ijid.2020.04.065. - DOI - PMC - PubMed
    1. Della Gatta A N, Rizzo R, Pilu G, Simonazzi G. Coronavirus disease 2019 during pregnancy: a systematic review of reported cases. Am J Obstet Gynecol. 2020;223(01):36–41. doi: 10.1016/j.ajog.2020.04.013. - DOI - PMC - PubMed
    1. Kyle M H, Glassman M E, Khan A, Fernández C R, Hanft E, Emeruwa U N et al.A review of newborn outcomes during the COVID-19 pandemic. Semin Perinatol. 2020;44(07):151286. doi: 10.1016/j.semperi.2020.151286. - DOI - PMC - PubMed

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