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Review
. 2021 May 17:9:665591.
doi: 10.3389/fcell.2021.665591. eCollection 2021.

Roles of Lipid Peroxidation-Derived Electrophiles in Pathogenesis of Colonic Inflammation and Colon Cancer

Lei Lei  1   2 , Jianan Zhang  2 , Eric A Decker  2 , Guodong Zhang  2   3
Affiliations
Review

Roles of Lipid Peroxidation-Derived Electrophiles in Pathogenesis of Colonic Inflammation and Colon Cancer

Lei Lei et al. Front Cell Dev Biol. .

Abstract

Redox stress is a common feature of gut disorders such as colonic inflammation (inflammatory bowel disease or IBD) and colorectal cancer (CRC). This leads to increased colonic formation of lipid-derived electrophiles (LDEs) such as 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), trans, trans-2,4-decadienal (tt-DDE), and epoxyketooctadecenoic acid (EKODE). Recent research by us and others support that treatment with LDEs increases the severity of colitis and exacerbates the development of colon tumorigenesis in vitro and in vivo, supporting a critical role of these compounds in the pathogenesis of IBD and CRC. In this review, we will discuss the effects and mechanisms of LDEs on development of IBD and CRC and lifestyle factors, which could potentially affect tissue levels of LDEs to regulate IBD and CRC development.

Keywords: colonic inflammation; colorectal cancer; inflammatory bowel disease; lipid peroxidation; oxidative stress.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Roles of ROS-produced lipid-derived electrophiles (LDE) compounds in pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC).
See this image and copyright information in PMC

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