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. 2021 May;76(5-6):519-524.

[Multidisciplinary management of the primary liver cancers]

[Article in French]
O Detry  1 , F Troisfontaine  2 , N Meurisse  1 , J Delwaide  3 , A Lamproye  3 , O Warling  3 , A Jadoul  4 , C Loly  3 , J Collignon  2
Affiliations
  • PMID: 34080390
Free article

[Multidisciplinary management of the primary liver cancers]

[Article in French]
O Detry et al. Rev Med Liege. 2021 May.
Free article

Abstract
in English, French

In Belgium and around the world, the incidence of primary malignant liver tumours is increasing, both for hepatocarcinoma and cholangiocarcinoma. Their curative treatment is based on multidisciplinary and specialized care, of which surgery (including liver transplantation) remains the cornerstone, often associated with other logoregional treatments, as radioembolisation, radiofrequency ablation, and chemoembolisation. For advanced cases, the prognosis remains poor, in particular due to a certain chemoresistance of these tumours. New treatments include targeted therapies (including various tyrosine kinase inhibitors) and immunotherapy. A specialized multidisciplinary discussion is therefore necessary to define the best therapeutic management, individualized to each patient. In this article, the authors review the most recent data relating to the treatment of hepatocarcinoma and cholangiocarcinoma.

En Belgique et dans le monde, l’incidence des tumeurs malignes primitives du foie augmente, tant pour l’hépatocarcinome que le cholangiocarcinome. Leur traitement curatif repose sur une prise en charge multidisciplinaire et spécialisée, dont la chirurgie (incluant la transplantation hépatique) reste la pièce angulaire, souvent associée à d’autres traitements logo-régionaux (radioembolisation, radiofréquence, chimio-embolisation). Pour les cas avancés, le pronostic reste sombre, notamment en raison d’une certaine chimiorésistance de ces tumeurs. Les nouvelles prises en charge incluent des thérapies ciblées (notamment, divers inhibiteurs de tyrosine kinase) et de l’immunothérapie. Une discussion pluridisciplinaire spécialisée est donc nécessaire pour définir la meilleure prise en charge thérapeutique, individualisée pour chaque patient. Dans cet article, les auteurs revoient les données récentes relatives au traitement de l’hépatocarcinome et du cholangiocarcinome.

Keywords: Cancer; Chemotherapy; Common bile duct; Gallbladder; Immunotherapy; Liver transplantation; Targeted therapy; Surgery.

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