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Case Reports
. 2023 Feb;36(1):173-175.
doi: 10.1177/08971900211021286. Epub 2021 Jun 3.

Intravenous Acetaminophen Overdose in an Infant With Toxicokinetic Data

Joshua Trebach  1   2 , Sarah G Mahonski  1   2 , Kristina Melchert  3 , Mary Ann Howland  1   2   4 , William K Chiang  1   2
Affiliations
Case Reports

Intravenous Acetaminophen Overdose in an Infant With Toxicokinetic Data

Joshua Trebach et al. J Pharm Pract. 2023 Feb.

Abstract

Case report: A 12-month-old (former 24 week gestational age), 8.7 kg male was hospitalized after an uneventful colostomy reversal. In the postoperative unit, the patient unintentionally received 1000 mg IV (114.9 mg/kg) acetaminophen instead of the intended 100 mg IV. Serial acetaminophen concentrations were drawn. The patient received IV Nacetylcysteine and ultimately had no adverse outcomes.

Discussion: This case report adds to the existing literature regarding toxicokinetics of IV APAP in infants. Our patient had a calculated ke of 0.263 h-1, correlating with a half-life of 2.63 hours. Based on current available data, the half-life of IV APAP in infants varies (2.6 to 4.9 hours). The reason for this variation is unknown and further research is needed in this area.

Keywords: acetaminophen; medication safety; pediatrics.

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