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Review
. 2021 Aug;36(8):1737-1743.
doi: 10.1002/mds.28680. Epub 2021 Jun 8.

Covid-19 Infection and Parkinsonism: Is There a Link?

Rabia Bouali-Benazzouz  1   2 , Abdelhamid Benazzouz  1   2
Affiliations
Review

Covid-19 Infection and Parkinsonism: Is There a Link?

Rabia Bouali-Benazzouz et al. Mov Disord. 2021 Aug.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an opportunistic pathogen that infects the upper respiratory tract in humans and causes serious illness, including fatal pneumonia and neurological disorders. Several studies have reported that SARS-CoV-2 may worsen the symptoms of Parkinson's disease (PD), with the potential to increase mortality rates in patients with advanced disease. The potential risk of SARS-CoV-2 to induce PD has also been suggested because the virus can enter the brain, where it can trigger cellular processes involved in neurodegeneration. In this review, we will discuss the potential of SARS-CoV-2 to exacerbate and cause certain neurological disorders, including PD. We will then elucidate its impact on the brain while examining its pathways and mechanisms of action. © 2021 International Parkinson and Movement Disorder Society.

Keywords: Covid-19; Parkinson's disease; SARS-CoV-2; neurological disorders; parkinsonism.

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References

    1. Hu B, Zeng L‐P, Yang X‐L, et al. Discovery of a rich gene pool of bat SARS‐related coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathog 2017;13(11):e1006698. - PMC - PubMed
    1. Luk HKH, Li X, Fung J, Lau SKP, Woo PCY. Molecular epidemiology, evolution and phylogeny of SARS coronavirus. Infect Genet Evol 2019;71:21–30. - PMC - PubMed
    1. Corman VM, Muth D, Niemeyer D, Drosten C. Hosts and Sources of Endemic Human Coronaviruses. Adv Virus Res 2018;100:163–188. 10.1016/bs.aivir.2018.01.001 - DOI - PMC - PubMed
    1. Lippi A, Domingues R, Setz C, Outeiro TF, Krisko A. SARS‐CoV‐2: at the crossroad between aging and neurodegeneration. Mov Disord 2020;35(5):716–720. - PMC - PubMed
    1. Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus‐infected pneumonia. N Engl J Med 2020;382(13):1199–1207. - PMC - PubMed

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