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. 2021 Sep;133(17-18):875-881.
doi: 10.1007/s00508-021-01880-5. Epub 2021 Jun 3.

Clinical and radiological characteristics of COVID‑19 patients without comorbidities : A single-center study

Saffet Ozturk  1 , Esin Kurtulus Ozturk  2 , Sibel Yildiz Kaya  3
Affiliations

Clinical and radiological characteristics of COVID‑19 patients without comorbidities : A single-center study

Saffet Ozturk et al. Wien Klin Wochenschr. 2021 Sep.

Abstract

Objective: To evaluate the clinical characteristics and detailed imaging features in coronavirus disease 2019 (COVID-19) patients without comorbidities.

Material and methods: This retrospective study included laboratory-confirmed and symptomatic COVID-19 patients without comorbid diseases who were admitted to our second level hospital between March 2020 and September 2020. We assessed the clinical, biochemical and imaging diagnostic parameters on admission. The patients were classified as non-severe and progress to severe group and then the initial parameters were compared.

Results: We enrolled 135 adult COVID-19 patients, 12 progressed to severe disease during hospitalization. Compared to the non-severe group, patients who progressed to severe were older (p < 0.001) and were more likely to manifest coughing (p = 0.011) and have higher lactate dehydrogenase (LDH) levels (p = 0.011). On chest computed tomography (CT) images, multilobar (p = 0.016), peripherally (p = 0.001) distributed mixed ground glass opacities and consolidation (p < 0.001), crazy paving (p = 0.007) and higher total CT severity score (p < 0.001) were significantly associated with severe disease.

Conclusion: Knowledge of the clinical and radiological parameters associated with disease severity might be useful to guide clinical decision-making for COVID-19 patients without comorbidities.

Keywords: COVID-19; Comorbidity; Computed tomography; Risk factor; Severity.

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Conflict of interest statement

S. Ozturk, E. Kurtulus Ozturk and S. Yildiz Kaya declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Typical CT imaging features of COVID-19. Consecutive axial chest CT images show multilobar peripherally distributed consolidation with ground glass opacities affecting the bilateral lungs CT SS: 8
Fig. 2
Fig. 2
Indeterminate CT imaging features of COVID-19. Unenhanced axial chest CT image shows unilateral peripheral ground glass opacities with perihilar consolidation CT SS: 2
Fig. 3
Fig. 3
Atypical CT imaging features for COVID-19. Axial CT images from two different patients showing isolated lobar consolidation (a) (CT SS: 2) and a solitary (arrow) ground glass nodule (b) (CT SS: 1)
See this image and copyright information in PMC

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