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. 2021 Dec;23(12):2482-2488.
doi: 10.1007/s12094-021-02647-0. Epub 2021 Jun 3.

Short-course radiotherapy in stage IV rectal cancer with resectable disease

M Cambray  1 , J González-Viguera  2 , M Macià  1 , F Losa  3 , G Soler  3 , R Frago  4 , J Maria Mullerat  5 , J Castellví  5 , E Guinó  6
Affiliations

Short-course radiotherapy in stage IV rectal cancer with resectable disease

M Cambray et al. Clin Transl Oncol. 2021 Dec.

Abstract

Introduction: Stage IV rectal cancer with resectable disease presents challenging issues, as the radical treatment of the whole disease is difficult. Surgery and chemotherapy (CT) play an unquestionable role, but the contribution of pelvic radiotherapy (RT) is not very clear.

Methods: In 2009, we established a prospective treatment protocol that included CT, short-course preoperative radiotherapy (SCRT) with surgery of the primary tumour and all metastatic locations.

Results: Forty patients were included. Eight (20%) patients did not receive CT due to significant comorbidities. Radical surgery treatment was possible in 22 (55%) patients. The mean follow-up was 42.81 months (3.63-105.97). Overall survival at 24 and 36 months was 71.4% and 58.2%, respectively. There was good local control of the disease, as 97.2% of pelvic surgeries were R0 and there were no local recurrences.

Conclusion: In stage IV with resectable metastatic disease, the proposed therapeutic regimen seems very appropriate in well selected patients able to tolerate the treatment. We bet on the role of pelvic RT, due to the good local control of the disease in our series.

Keywords: Rectal cancer; Resectable metastases; Short-course preoperative radiotherapy.

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References

    1. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al. Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg. 2006;93(10):1215–23. - DOI
    1. Van Gijn W, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12 year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol. 2011;12(6):575–82. - DOI
    1. Folkesson J, Birgisson H, Pahlman L, et al. Swedish rectal cancer trial: long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol. 2005;23(24):5644–50. - DOI
    1. Sebag-Montefiore D, Stephens RJ, Steele R, et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet. 2009;373:811–20. - DOI
    1. Veenhof AA, Kropman RH, Engel AF, et al. Preoperative radiation therapy for locally advanced rectal cancer: a comparison between two different time intervals to surgery. Int J Colorectal Dis. 2007;22(5):507–13. - DOI

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