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Case Reports
. 2021 Dec;46(8):1615-1617.
doi: 10.1111/ced.14784. Epub 2021 Aug 19.

COVID-19 vaccine-induced Stevens-Johnson syndrome

S Dash  1 , C S Sirka  1 , S Mishra  1 , P Viswan  1
Affiliations
Case Reports

COVID-19 vaccine-induced Stevens-Johnson syndrome

S Dash et al. Clin Exp Dermatol. 2021 Dec.

Abstract

Herein, we are reporting a case of Stevens–Johnson syndrome due to COVID‐19 vaccine, which has been proved by history taking, clinical examination and histopathology. To the best of our knowledge we are reporting the first case of COVID‐19 vaccine‐induced Stevens–Johnson syndrome.

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Figures

Figure 1
Figure 1
(a) Large sheets of necrosed skin in front of trunk, with a few areas showing bullae; (b) involvement of the face with erosions in palpebral conjunctiva and necrotic crusting over lips.
Figure 2
Figure 2
(a) Orthokeratosis with epidermal atrophy, scattered degenerated apoptotic keratinocytes, patchy areas of basal cell degeneration and interface dermatitis, perivascular and periadnexal inflammatory cell infiltrate, and extravasation of erythrocytes in the dermis; (b) apoptotic keratinocytes (arrow), upper dermal oedema and extravasation of erythrocytes. Haematoxylin and eosin, original magnification (a) × 50; (b) × 400.
See this image and copyright information in PMC

Comment in

  • Stevens-Johnson syndrome after ChAdOx1 nCoV-19 vaccine.
    da Cruz Gouveia PA, Cavalcanti LNF, Alves LCF, Almeida DM, Barretto LWA. da Cruz Gouveia PA, et al. Indian J Dermatol Venereol Leprol. 2022 Sep-Oct;88(5):702. doi: 10.25259/IJDVL_941_2021. Indian J Dermatol Venereol Leprol. 2022. PMID: 35986626 No abstract available.

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