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Comment
. 2021 Jun 2;109(11):1755-1757.
doi: 10.1016/j.neuron.2021.05.015.

It's lights out for presynaptic terminals

Xinyi Jenny He  1 , Matthew R Banghart  2
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Free article
Comment

It's lights out for presynaptic terminals

Xinyi Jenny He et al. Neuron. .
Free article

Abstract

Reliable optogenetic tools for sustained, projection-specific presynaptic silencing have been elusive. Recently in Neuron, Mahn et al. (2021) and Copits et al. (2021) describe how the light-activated inhibitory GPCRs eOPN3 and PPO can be used to reversibly suppress synaptic transmission in mice.

Keywords: GPCR; dopamine; optogenetics; presynaptic; rhodopsin; silencing; synaptic transmission.

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  • Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin.
    Mahn M, Saraf-Sinik I, Patil P, Pulin M, Bitton E, Karalis N, Bruentgens F, Palgi S, Gat A, Dine J, Wietek J, Davidi I, Levy R, Litvin A, Zhou F, Sauter K, Soba P, Schmitz D, Lüthi A, Rost BR, Wiegert JS, Yizhar O. Mahn M, et al. Neuron. 2021 May 19;109(10):1621-1635.e8. doi: 10.1016/j.neuron.2021.03.013. Epub 2021 May 11. Neuron. 2021. PMID: 33979634 Free PMC article.
  • A photoswitchable GPCR-based opsin for presynaptic inhibition.
    Copits BA, Gowrishankar R, O'Neill PR, Li JN, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, Shirley SE, Ma KKL, Vasquez AM, Stander MC, Kalyanaraman V, Vogt SK, Samineni VK, Patriarchi T, Tian L, Gautam N, Sunahara RK, Gereau RW 4th, Bruchas MR. Copits BA, et al. Neuron. 2021 Jun 2;109(11):1791-1809.e11. doi: 10.1016/j.neuron.2021.04.026. Epub 2021 May 11. Neuron. 2021. PMID: 33979635 Free PMC article.

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