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Comment
. 2021 Jun 2;109(11):1757-1760.
doi: 10.1016/j.neuron.2021.05.018.

Neuronal intranuclear inclusion disease: Polyglycine protein is the culprit

Michelle E Ehrlich  1 , Lisa M Ellerby  2
Affiliations
Comment

Neuronal intranuclear inclusion disease: Polyglycine protein is the culprit

Michelle E Ehrlich et al. Neuron. .

Abstract

In this issue of Neuron, Boivin et al. (2021) show that a polyglycine-expanded protein, uN2CpolyG, is translated from an expansion of GGC repeats in the 5' UTR of the NOTCH2NLC (Notch homolog 2 N-terminal-like C) gene, defining a new pathological mechanism for neuronal intranuclear inclusion diseases (NIID).

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Figures

Figure 1.
Figure 1.
Schematic of the features of NIID, production of uN2CpolyQ protein, and future studies proposed for NIID.
See this image and copyright information in PMC

Comment on

References

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