Neuronal enhancers get a break
- PMID: 34081919
- DOI: 10.1016/j.neuron.2021.05.008
Neuronal enhancers get a break
Abstract
Emerging evidence shows that neuronal DNA is continuously broken and repaired in a non-random fashion within the genome. Two recent studies, Wu et al. (2021) and Reid et al. (2021), use sequencing of newly synthesized DNA in post-mitotic neurons to map hotspots of DNA repair across the genome. Wu et al. (2021) further show that the repair sites are associated with single-stranded DNA breaks that predominantly occur on neuronal enhancers at sites of CpG methylation.
Copyright © 2021. Published by Elsevier Inc.
Comment on
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Neuronal enhancers are hotspots for DNA single-strand break repair.Nature. 2021 May;593(7859):440-444. doi: 10.1038/s41586-021-03468-5. Epub 2021 Mar 25. Nature. 2021. PMID: 33767446 Free PMC article.
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Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons.Science. 2021 Apr 2;372(6537):91-94. doi: 10.1126/science.abb9032. Science. 2021. PMID: 33795458 Free PMC article.
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