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Comment
. 2021 Jun 2;109(11):1766-1768.
doi: 10.1016/j.neuron.2021.05.008.

Neuronal enhancers get a break

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Neuronal enhancers get a break

Vishnu Dileep et al. Neuron. .
Free article

Abstract

Emerging evidence shows that neuronal DNA is continuously broken and repaired in a non-random fashion within the genome. Two recent studies, Wu et al. (2021) and Reid et al. (2021), use sequencing of newly synthesized DNA in post-mitotic neurons to map hotspots of DNA repair across the genome. Wu et al. (2021) further show that the repair sites are associated with single-stranded DNA breaks that predominantly occur on neuronal enhancers at sites of CpG methylation.

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  • Neuronal enhancers are hotspots for DNA single-strand break repair.
    Wu W, Kargbo-Hill SE, Nathan WJ, Paiano J, Callen E, Wang D, Shinoda K, van Wietmarschen N, Colón-Mercado JM, Zong D, De Pace R, Shih HY, Coon S, Parsadanian M, Pavani R, Hanzlikova H, Park S, Jung SK, McHugh PJ, Canela A, Chen C, Casellas R, Caldecott KW, Ward ME, Nussenzweig A. Wu W, et al. Nature. 2021 May;593(7859):440-444. doi: 10.1038/s41586-021-03468-5. Epub 2021 Mar 25. Nature. 2021. PMID: 33767446 Free PMC article.
  • Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons.
    Reid DA, Reed PJ, Schlachetzki JCM, Nitulescu II, Chou G, Tsui EC, Jones JR, Chandran S, Lu AT, McClain CA, Ooi JH, Wang TW, Lana AJ, Linker SB, Ricciardulli AS, Lau S, Schafer ST, Horvath S, Dixon JR, Hah N, Glass CK, Gage FH. Reid DA, et al. Science. 2021 Apr 2;372(6537):91-94. doi: 10.1126/science.abb9032. Science. 2021. PMID: 33795458 Free PMC article.

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