Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jun 3;18(1):114.
doi: 10.1186/s12985-021-01589-x.

Functional cure for chronic hepatitis B: accessibility, durability, and prognosis

Aixin Song  1 , Xiao Lin  1 , Xinyue Chen  2
Affiliations
Review

Functional cure for chronic hepatitis B: accessibility, durability, and prognosis

Aixin Song et al. Virol J. .

Abstract

Hepatitis B surface antigen (HBsAg) clearance is regarded as the ideal endpoint for antiviral treatment in terms of drug withdrawal safety and improvements in prognosis. However, the overall rate of HBsAg clearance is low and differs based on treatment method and course. The recent application of combined and extended treatment strategies have improved the HBsAg clearance rate, and several patients achieved HBsAg clearance in clinical treatment. In addition, the durability of and clinical outcomes after HBsAg clearance have become the focus of both researchers and clinicians. This article reviews HBsAg clearance in terms of accessibility, durability, improvements in prognosis and relevant advances.

Keywords: HBsAg clearance; Hepatitis B virus; Prognosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Liaw YF, Chu CM. Hepatitis B virus infection. Lancet. 2009;373(9663):582–592. doi: 10.1016/S0140-6736(09)60207-5. - DOI - PubMed
    1. Trépo C, Chan HL, Lok A. Hepatitis B virus infection. Lancet. 2014;384(9959):2053–2063. doi: 10.1016/S0140-6736(14)60220-8. - DOI - PubMed
    1. Terrault NA, Bzowej NH, Chang KM, et al. AASLD guidelines for treatment of chronic hepatitis B. Hepatology (Baltimore, MD) 2016;63(1):261–283. doi: 10.1002/hep.28156. - DOI - PMC - PubMed
    1. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol. 2017;67(2):370–98. - PubMed
    1. Block TM, Gish R, Guo H, et al. Chronic hepatitis B: what should be the goal for new therapies? Antiviral Res. 2013;98(1):27–34. doi: 10.1016/j.antiviral.2013.01.006. - DOI - PMC - PubMed

Publication types

LinkOut - more resources