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Review
. 2021 Jun 3;18(1):114.
doi: 10.1186/s12985-021-01589-x.

Functional cure for chronic hepatitis B: accessibility, durability, and prognosis

Aixin Song  1 , Xiao Lin  1 , Xinyue Chen  2
Affiliations
Review

Functional cure for chronic hepatitis B: accessibility, durability, and prognosis

Aixin Song et al. Virol J. .

Abstract

Hepatitis B surface antigen (HBsAg) clearance is regarded as the ideal endpoint for antiviral treatment in terms of drug withdrawal safety and improvements in prognosis. However, the overall rate of HBsAg clearance is low and differs based on treatment method and course. The recent application of combined and extended treatment strategies have improved the HBsAg clearance rate, and several patients achieved HBsAg clearance in clinical treatment. In addition, the durability of and clinical outcomes after HBsAg clearance have become the focus of both researchers and clinicians. This article reviews HBsAg clearance in terms of accessibility, durability, improvements in prognosis and relevant advances.

Keywords: HBsAg clearance; Hepatitis B virus; Prognosis.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Liaw YF, Chu CM. Hepatitis B virus infection. Lancet. 2009;373(9663):582–592. doi: 10.1016/S0140-6736(09)60207-5. - DOI - PubMed
    1. Trépo C, Chan HL, Lok A. Hepatitis B virus infection. Lancet. 2014;384(9959):2053–2063. doi: 10.1016/S0140-6736(14)60220-8. - DOI - PubMed
    1. Terrault NA, Bzowej NH, Chang KM, et al. AASLD guidelines for treatment of chronic hepatitis B. Hepatology (Baltimore, MD) 2016;63(1):261–283. doi: 10.1002/hep.28156. - DOI - PMC - PubMed
    1. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol. 2017;67(2):370–98. - PubMed
    1. Block TM, Gish R, Guo H, et al. Chronic hepatitis B: what should be the goal for new therapies? Antiviral Res. 2013;98(1):27–34. doi: 10.1016/j.antiviral.2013.01.006. - DOI - PMC - PubMed

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