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Review
. 2021 Feb 15;10(2):LMT45.
doi: 10.2217/lmt-2020-0029.

Current clinical trials and patent update on lung cancer: a retrospective review

Harshul Batra  1 , Shrikant Pawar  2 , Dherya Bahl  3
Affiliations
Review

Current clinical trials and patent update on lung cancer: a retrospective review

Harshul Batra et al. Lung Cancer Manag. .

Abstract

Several clinical trials using different interventions are currently being sponsored to combat lung cancer at its different stages. The purpose of this study was to provide a portfolio of those trials. All active, open and recruiting clinical trials registered at ClinicalTrials.gov up to March 2018 were included. Information related to 6092 registered lung cancer trials was downloaded. Phase II trials were in the majority, comprising nearly 48.7% of total clinical trials with industry the major sponsor (41.3%) followed by NIH (12.3%). Multicenter studies were the norm accounting for 47.9% and the main study location was the USA (50.9%). Common interventions were radiation (26%), surgery (22%) and EGFR inhibitors (17%). Patent information includes major patent filing office and sponsors. The data analysis provides a comprehensive description of lung cancer trials.

Keywords: chemotherapy; clinical trials; clinicaltrials.gov; lung cancer; lung cancer patents.

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Conflict of interest statement

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties. No writing assistance was utilized in the production of this manuscript.

Figures

Figure 1.
Figure 1.. Flowchart of study selection.
Figure 2.
Figure 2.. Types of treatment for lung cancer in clinical trials Phase I–IV.
(A) Types therapy for treating lung cancer. (B) Biomarker analysis studies in clinical trials.
Figure 3.
Figure 3.. Clinical trials time line for patient enrollment.
(A) Phase II and (B) Phase III.
See this image and copyright information in PMC

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