Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct-Dec;16(4):470-478.
doi: 10.4183/aeb.2020.470.

The influence of diet therapeutic intervention on the sarcopenic index of patients with metabolic syndrome

T C Ghitea  1 , S Vlad  2 , D Birle  3 , D M Tit  1 , L Lazar  4 , C Nistor-Cseppento  4 , T Behl  5 , S Bungau  1
Affiliations

The influence of diet therapeutic intervention on the sarcopenic index of patients with metabolic syndrome

T C Ghitea et al. Acta Endocrinol (Buchar). 2020 Oct-Dec.

Abstract

Introduction: The published data showed the importance of metabolic control in preventing complications in metabolic syndrome (MS) and the role of nutritional medical therapy in glycemic control and in the control of dyslipidemia, hypertension, weight loss/normalization (in overweight or malnourished subjects).

Objectives: This study follows the evolution of sarcopenic index (SI) and other clinical parameters (body mass index (BMI), homeostasis evaluation index (HOMA index)) correlated with MS after diet therapy or diet therapy combined with sports, in patients with MS.

Patients and methods: Our research was conducted during 12 months, on 110 patients >18 years of age, with HOMA index>2, divided into three groups: control group (CG, N=20), diet therapy group (DTG, N=58), diet therapy and sports group (DTSG, N=32). HOMA index for insulin resistance was calculated as the product of resting plasma insulin (in microunits/milliliter) and plasma glucose (in millimoles/liter), divided by 22.5. SI was determined using BIA, as being the ratio between muscle mass and fat mass, measured in cm2/m2.

Results: A significant decrease of BMI (p<0.05) in DTG (from 31.63 to 24.50) and DTSG (from 30.18 to 24.17) vs. CG was observed (Pearson coefficient r=0.281, p<0.001). Weight status changed significantly (p<0.05) in the high-risk patients. There was a significant decrease of HOMA index (p<0.05) in DTG (from 5.93 to 2.57), DTSG (from 3.93 to 2.23), and in CG an increase was observed (from 3.15 to 3.37).

Conclusion: The best results in the prevention/ treatment of sarcopenia in MS patients were obtained for DTSG, which benefited from both the positive effect of diet and physical activity.

Keywords: HOMA index; diet therapeutic intervention; metabolic syndrome; obesity; sarcopenic index.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The relationship between muscle and adipose tissue. The mechanism that leads to the development of sarcopenia. (TNF-alpha: tumor necrosis factor-alpha; IL-6: interleukin-6; MCP1: monocyte chemoattractant protein-1).
Figure 2.
Figure 2.
BMI at the base line, at 6 months, and at the end of the study in CG, DTG and DTSG.
Figure 3.
Figure 3.
Descriptive and inferential statistics for comparing clinical and paraclinical indicators for all three researched groups, at the end of the intervention.
Figure 4.
Figure 4.
Graphical representation of the weight status in both genders: A.at the base line; B. final.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Rubio-Ruiz ME, Guarner-Lans V, Pérez-Torres I, Soto ME. Mechanisms underlying metabolic syndrome-related sarcopenia and possible therapeutic measures. Int J Mol Sci. 2019;20(3):647. - PMC - PubMed
    1. Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg P, Elia M, Gómez JM, Heitmann BL, Kent-Smith L, Melchior JC, Pirlich M, Scharfetter H, Schols AM, Pichard C. Composition of the ESPEN Working Group. Bioelectrical impedance analysis-part I: review of principles and methods. Clin Nutr. 2004;23(5):1226–1243. - PubMed
    1. Zamboni M, Rubele S, Rossi AP. Sarcopenia and obesity. Curr Opin Clin Nutr Metab Care. 2019;22(1):13–19. - PubMed
    1. Fonseca GWPD, Ribeiro de Souza F, dos Santos MR, Janieire de Nazaré Nunes Alves M. The role of exercise on sarcopenia. Cardiol Cardiovasc Med. 2020;4(5):540–562.
    1. Kir S, Ekiz K, Alacam H, Turkel R, Koroglu E, Altintop BL. The association between pro and anti-inflamatory markers with the components of metabolic syndrome. Acta Endocrinol (Buchar). 2019;15(4):430–435. - PMC - PubMed

LinkOut - more resources