Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 May 24;9(5):e04134.
doi: 10.1002/ccr3.4134. eCollection 2021 May.

Clozapine-induced gastroesophageal rumination in 22q11.2 Deletion Syndrome. A case report on gastroesophageal side effects management without renouncing clozapine's effectiveness

Tommaso Accinni  1 , Marianna Frascarelli  1 , Francesco Ghezzi  1 , Alessia Panzera  1 , Antonino Buzzanca  1 , Martina Fanella  1 , Carlo Di Bonaventura  1 , Luca Carlone  1 , Nicoletta Girardi  1 , Massimo Pasquini  1 , Fabio Di Fabio  1
Affiliations
Case Reports

Clozapine-induced gastroesophageal rumination in 22q11.2 Deletion Syndrome. A case report on gastroesophageal side effects management without renouncing clozapine's effectiveness

Tommaso Accinni et al. Clin Case Rep. .

Abstract

Despite entailing more severe and uncommon side effects in 22q11.2DS compared to idiopathic schizophrenia, we strongly believe that clozapine should continue to be considered the gold standard for all treatment-resistant schizophrenia, even in 22qDS.

Keywords: genetics; pharmacology; psychiatry.

PubMed Disclaimer

Conflict of interest statement

None declared.

References

    1. McDonald‐McGinn DM, Sullivan KE, Marino B, et al. 22q11.2 deletion syndrome. Nat Rev Dis Prim. 2015;19:1‐15071. - PMC - PubMed
    1. Botto LD, May K, Fernhoff PM, et al. A population‐based study of the 22q11.2 Deletion: Phenotype, incidence, and contribution to major birth defects in the population. Pediatrics. 2003;112:101‐107. - PubMed
    1. Murphy KC. Schizophrenia and velo‐cardio‐facial syndrome. Lancet. 2002;359:426‐430. - PubMed
    1. Verhoeven WMA, Egger JIM. Atypical antipsychotics and relapsing psychoses in 22q11.2 deletion syndrome: A long‐term evaluation of 28 patients. Pharmacopsychiatry. 2015;48:104‐110. - PubMed
    1. Siskind D, Siskind V, Kisely S. Clozapine response rates among people with treatment‐resistant schizophrenia: data from a systematic review and meta‐analysis. Can J Psychiatry. 2017;62:772‐777. - PMC - PubMed

Publication types

LinkOut - more resources