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Case Reports
. 2021 Apr 1;6(5):131-134.
doi: 10.5194/jbji-6-131-2021. eCollection 2021.

Coagulation disorders during treatment with cefazolin and rifampicin: rare but dangerous

Ines Kouki  1 , Clémence Montagner  1 , Wladimir Mauhin  1 , Jonathan London  1 , Thierry Lazard  2 , Sylvie Grimbert  3 , Valérie Zeller  4 , Olivier Lidove  1
Affiliations
Case Reports

Coagulation disorders during treatment with cefazolin and rifampicin: rare but dangerous

Ines Kouki et al. J Bone Jt Infect. .

Abstract

We describe a 79-year-old man with spondylodiscitis and unknown pathogen, treated with cefazolin and rifampicin. He developed a massive digestive hemorrhage. Prothrombin time was prolonged with severe vitamin-K-dependent clotting-factor deficiency. Severe bleeding can occur during cefazolin and rifampicin use. This deficiency should be assessed before prescribing cefazolin-rifampicin and prothrombin time monitored.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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