Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec;73(6):1513-1519.
doi: 10.1007/s43440-021-00286-4. Epub 2021 Jun 4.

Use of glucocorticoids and azithromycin in the therapy of COVID-19

Miguel de Lemos Neto  1 , Rafael Costa Vieira Alexandre  2 , Rafaela Oliveira Gallart Morra  2 , Juliana Aparecida Souza da Paz  3 , Shana Priscila Coutinho Barroso  3 , Angela Castro Resende  4 , Daniel J M de Medeiros-Lima  5 , Pedro Celso Braga Alexandre  2
Affiliations
Review

Use of glucocorticoids and azithromycin in the therapy of COVID-19

Miguel de Lemos Neto et al. Pharmacol Rep. 2021 Dec.

Abstract

In December 2019, a new variant coronavirus, SARS-CoV-2, emerged in China, which was initially described as a pneumonia of an unknown agent. The new coronavirus spreads mainly by person-to-person transmission through close contact. The pathophysiology of COVID-19 is related to a complex immune system response that varies between people and, in severe cases of the disease, is characterized by excessive responses called "cytokine storms," which are associated with complications that can lead to a state of hypercoagulation and death. Glucocorticoids and azithromycin are drugs that may be effective in the treatment. This review aims to highlight the clinical findings that demonstrate the effectiveness of glucocorticoid and azithromycin therapy in the treatment of COVID-19. To date, many drugs have been studied for use in combination therapy, and the rapid expansion of knowledge about the virology of SARS-CoV-2 generates a more accurate direction in therapy.

Keywords: Antibiotics; COVID-19; Glucocorticoids; SARS-CoV-2.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Pimentel RMM, Daboin BEG, de Oliveira AG, Macedo H. The dissemination of COVID-19: an expectant and preventive role in global health. J Hum Growth Dev. 2020;30:135–140. doi: 10.7322/JHGD.V30.9976. - DOI
    1. Kakodkar P, Kaka N, Baig M. A comprehensive literature review on the clinical presentation, and management of the pandemic coronavirus disease 2019 (COVID-19) Cureus. 2020;12(4):e7560. doi: 10.7759/cureus.7560. - DOI - PMC - PubMed
    1. Xu X, Ong YK, Wang DY. Role of adjunctive treatment strategies in COVID-19 and a review of international and national clinical guidelines. Mil Med Res. 2020;7(1):22. doi: 10.1186/s40779-020-00251-x. - DOI - PMC - PubMed
    1. Fu Y, Cheng Y, Wu Y. Understanding SARS-CoV-2-mediated inflammatory responses: from mechanisms to potential therapeutic tools. Virol Sin. 2020;35(3):266–271. doi: 10.1007/s12250-020-00207-4. - DOI - PMC - PubMed
    1. Malik YA. Properties of coronavirus and SARS-CoV-2. Malays J Pathol. 2020;42(1):3–11. - PubMed