Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug;28(31):41533-41551.
doi: 10.1007/s11356-021-14675-y. Epub 2021 Jun 3.

Uncurtaining the pivotal role of ABC transporters in diabetes mellitus

Tapan Behl  1 , Aayush Sehgal  2 , Madhuri Grover  3 , Sukhbir Singh  2 , Neelam Sharma  2 , Saurabh Bhatia  4   5 , Ahmed Al-Harrasi  5 , Lotfi Aleya  6 , Simona Bungau  7
Affiliations
Review

Uncurtaining the pivotal role of ABC transporters in diabetes mellitus

Tapan Behl et al. Environ Sci Pollut Res Int. 2021 Aug.

Abstract

The metabolic disorders are the edge points for the initiation of various diseases. These disorders comprised of several diseases including diabetes, obesity, and cardiovascular complications. Worldwide, the prevalence of these disorders is increasing day by day. The world's population is at higher threat of developing metabolic disease, especially diabetes. Therefore, there is an impregnable necessity of searching for a newer therapeutic target to reduce the burden of these disorders. Diabetes mellitus (DM) is marked with the dysregulated insulin secretion and resistance. The lipid and glucose transporters portray a pivotal role in the metabolism and transport of both of these. The excess production of lipid and glucose and decreased clearance of these leads to the emergence of DM. The ATP-binding cassette transporters (ABCT) are important for the metabolism of glucose and lipid. Various studies suggest the key involvement of ABCT in the pathologic process of different diseases. In addition, the involvement of other pathways, including IGF signaling, P13-Akt/PKC/MAPK signaling, and GLP-1 via regulation of ABCT, may help develop new treatment strategies to cope with insulin resistance dysregulated glucose metabolism, key features in DM.

Keywords: ABC Transporters; Diabetes mellitus; Glucose Transporters; Lipid Transporters; Metabolic Syndrome; Obesity.

PubMed Disclaimer

References

    1. Aguilar-Salinas CA, Muñoz-Hernandez LL, Cobos-Bonilla M, Ramírez-Márquez MR, Ordoñez-Sanchez ML, Mehta R, Medina-Santillan R, Tusie-Luna MT (2013) The R230C variant of the ATP binding cassette protein A1 (ABCA1) gene is associated with a decreased response to glyburide therapy in patients with type 2 diabetes mellitus. Metabolism 62:638–641. https://doi.org/10.1016/j.metabol.2012.11.006 - DOI
    1. Ahmad MM, Brema IA, Almalki MH (2019) SGLT2 inhibitors therapy in type 2 diabetes mellitus. Type 2 Diabetes-From Pathophysiol to Mod Manag. IntechOpen. https://doi.org/10.5772/intechopen.84152
    1. Akiyama M (2014) The roles of ABCA12 in epidermal lipid barrier formation and keratinocyte differentiation. Biochim Biophys Acta (BBA)-Mol Cell Biol Lipids 1841:435–440. https://doi.org/10.1016/j.bbalip.2013.08.009 - DOI
    1. Akiyama M (2020) Acylceramide is a key player in skin barrier function: insight into the molecular mechanisms of skin barrier formation and ichthyosis pathogenesis. FEBS J 288:2119–2130. https://doi.org/10.1111/febs.15497 - DOI
    1. Alam A, Küng R, Kowal J, McLeod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP (2018) Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proc Natl Acad Sci 115:E1973–E1982. https://doi.org/10.1073/pnas.1717044115 - DOI

LinkOut - more resources