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. 2021 Nov;28(11):3193-3199.
doi: 10.1007/s43032-021-00639-7. Epub 2021 Jun 3.

Application of Pulsed Rhythmic Drug Administration to Ovulation Induction Therapy in PCOS Patients with Clomiphene-Resistance: a Retrospective Research

Xinyue Zhang  1 , Aiyan Zheng  2 , Jihong Yang  1 , Ting Feng  1 , Yan Zhang  1 , Yingying Hao  1 , Suying Li  1 , Yun Qian  3
Affiliations

Application of Pulsed Rhythmic Drug Administration to Ovulation Induction Therapy in PCOS Patients with Clomiphene-Resistance: a Retrospective Research

Xinyue Zhang et al. Reprod Sci. 2021 Nov.

Abstract

There is currently a dispute over the choice of ovulation induction treatment for infertile women with polycystic ovary syndrome (PCOS). The objective of this study is to compare the therapeutic effect of pulsed rhythmic administration protocol (PRAP) with conventional letrozole + human menopausal gonadotropin (HMG) in patients with clomiphene-resistance polycystic ovary syndrome (PCOS). A retrospective analysis of 821 intrauterine insemination (IUI) cycles between January 2015 and January 2020 was performed. Of these, 483 cycles were treated with a pulsed rhythmic administration protocol (PRAP), and 338 cycles were treated with conventional letrozole + HMG protocol (LHP). The therapeutic effect of the two protocols has been compared. The pregnancy rate was 18.07% in the LHP and 27.07% in the PRAP. The ongoing pregnancy rate in LHP was 14.46% and in PRAP was 22.73%. The research suggests that PRAP is more effective than LHP and could be an adequate ovulation induction strategy for the IUI cycle of patients with clomiphene-resistance PCOS.

Keywords: Intrauterine insemination; Polycystic ovary syndrome; Pulsed rhythmic administration.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of clomiphene-resistance PCOS patients’ inclusion in the Reproductive Medical Center of the Second Affiliated Hospital of Nanjing Medical University. np: number of patients, nc: number of cycles
Fig. 2
Fig. 2
The pulsed rhythmic administration protocol
See this image and copyright information in PMC

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