Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity

Junyan Han^#¹, Ning Zhang^#², Danying Chen^#¹, Yuhuan Gong^#^{2

3}, Guoli Li^#¹, Yaxian Kong¹, Lin Pu⁴, Chen Chen¹, Jingyuan Liu⁴, Qi Wang⁵, Ju Zhang¹, Xuesen Zhao¹, Juan Du¹, Kai Han¹, Chuan Song¹, Linghang Wang⁶, Mingxi Hua¹, Yu Hao¹, Rui Song⁷, Yangzi Song⁸, Fengting Yu⁸, Siyuan Yang⁶, Haofeng Xiong⁴, Wei Zhang⁷, George F Gao^{9

10}, Fujie Zhang¹¹, Ang Li¹², Hui Zeng¹³, Yuhai Bi^{14

15}

Affiliations

¹ Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
² CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China.
³ Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
⁴ Intensive Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
⁵ Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
⁶ Laboratory of Infectious Diseases Center of Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
⁷ The Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
⁸ Clinical Center for HIV/AIDS, Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
⁹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. gaof@im.ac.cn.
¹⁰ University of Chinese Academy of Sciences, Beijing, 100049, China. gaof@im.ac.cn.
¹¹ Clinical Center for HIV/AIDS, Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. treatment@chinaaids.cn.
¹² Intensive Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. liang@ccmu.edu.cn.
¹³ Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. zenghui@ccmu.edu.cn.
¹⁴ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. beeyh@im.ac.cn.
¹⁵ University of Chinese Academy of Sciences, Beijing, 100049, China. beeyh@im.ac.cn.

^# Contributed equally.

PMID: 34086155
PMCID: PMC8176871
DOI: 10.1007/s11427-020-1947-y

Comment

Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity

Junyan Han et al. Sci China Life Sci. 2022 Jan.

. 2022 Jan;65(1):223-226.

doi: 10.1007/s11427-020-1947-y. Epub 2021 Jun 2.

Authors

Affiliations

¹ Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
² CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China.
³ Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
⁴ Intensive Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
⁵ Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
⁶ Laboratory of Infectious Diseases Center of Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
⁷ The Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
⁸ Clinical Center for HIV/AIDS, Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
⁹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. gaof@im.ac.cn.
¹⁰ University of Chinese Academy of Sciences, Beijing, 100049, China. gaof@im.ac.cn.
¹¹ Clinical Center for HIV/AIDS, Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. treatment@chinaaids.cn.
¹² Intensive Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. liang@ccmu.edu.cn.
¹³ Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. zenghui@ccmu.edu.cn.
¹⁴ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. beeyh@im.ac.cn.
¹⁵ University of Chinese Academy of Sciences, Beijing, 100049, China. beeyh@im.ac.cn.

^# Contributed equally.

PMID: 34086155
PMCID: PMC8176871
DOI: 10.1007/s11427-020-1947-y

No abstract available

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Evolution of antibody immunity to SARS-CoV-2.
Gaebler C, Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Tokuyama M, Cho A, Jankovic M, Schaefer-Babajew D, Oliveira TY, Cipolla M, Viant C, Barnes CO, Bram Y, Breton G, Hägglöf T, Mendoza P, Hurley A, Turroja M, Gordon K, Millard KG, Ramos V, Schmidt F, Weisblum Y, Jha D, Tankelevich M, Martinez-Delgado G, Yee J, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Robbiani DF, Zhao Z, Gazumyan A, Schwartz RE, Hatziioannou T, Bjorkman PJ, Mehandru S, Bieniasz PD, Caskey M, Nussenzweig MC. Gaebler C, et al. Nature. 2021 Mar;591(7851):639-644. doi: 10.1038/s41586-021-03207-w. Epub 2021 Jan 18. Nature. 2021. PMID: 33461210 Free PMC article.

References

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1. Gaebler C, Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Tokuyama M, Cho A, Jankovic M, Schaefer-Babajew D, Oliveira TY, et al. Evolution of antibody immunity to SARS-CoV-2. Nature. 2021;591:639–644. doi: 10.1038/s41586-021-03207-w. - DOI - PMC - PubMed
1. Ibarrondo FJ, Fulcher JA, Goodman-Meza D, Elliott J, Hofmann C, Hausner MA, Ferbas KG, Tobin NH, Aldrovandi GM, Yang OO. Rapid decay of Anti-SARS-CoV-2 antibodies in persons with mild COVID-19. N Engl J Med. 2020;383:1085–1087. doi: 10.1056/NEJMc2025179. - DOI - PMC - PubMed
1. Long QX, Liu BZ, Deng HJ, Wu GC, Deng K, Chen YK, Liao P, Qiu JF, Lin Y, Cai XF, et al. Antibody responses to SARS-CoV-2 in patients with COVID-19. Nat Med. 2020;26:845–848. doi: 10.1038/s41591-020-0897-1. - DOI - PubMed

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Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity

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Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity

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